Publications by authors named "Kiran J K Rikhraj"
Article Synopsis
- * The researchers included data from eight randomized controlled trials involving 4,561 patients, focusing on conditions like cardiac arrest and septic shock, and evaluated the impact on mortality, neurologic outcomes, and renal function.
- * The findings revealed no significant differences in mortality (RR 1.06), favorable neurologic outcomes (RR 0.99), or need for renal replacement therapy (RR 0.97) between the two MAP thresholds, suggesting similar patient outcomes regardless of MAP level. *
Importance: Brain injury biomarkers released into circulation from the injured neurovascular unit are important prognostic tools in patients with cardiac arrest who develop hypoxic ischemic brain injury (HIBI) after return of spontaneous circulation (ROSC).
Objective: To assess the neuroprognostic utility of bloodborne brain injury biomarkers in patients with cardiac arrest with HIBI.
Data Sources: Studies in electronic databases from inception to September 15, 2021.
The use of cerebral autoregulation monitoring to identify patient-specific optimal mean arterial pressure (MAP) has emerged as a technique to augment cerebral oxygen delivery in post-cardiac arrest patients. Our systematic review aims to determine (a) the average MAP in these patients, (b) the feasibility of identifying MAP, (c) the brain tissue oxygenation levels when MAP is within proximity to the MAP and (d) the relationship between neurological outcome and MAP-targeted resuscitation strategies. We carried out this review in accordance with the PRISMA guidelines.
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