Surgical outcome of clipping in anterior circulation aneurysms.

Objective: To observe the outcome of surgical clipping in anterior circulation aneurysm in a modestly resourced hospital.

Methods: A retrospective cross-sectional study was conducted at Punjab Institute of Neurosciences Lahore, from August 2022 to July 2023. Seventy five patients meeting the inclusion criteria of age <65, saccular aneurysm of anterior circulation, and Hunt and Hess grade one or two were enrolled through non-probability convenience sampling.

EFFICACY OF ORAL VORICONAZOLE VERSUS ORAL ITRACONAZOLE, IN THE TREATMENT OF DERMATOPHYTE INFECTIONS.

Background: Dermatophyte infections are common in tropical areas with a humid climate. In recent times, it is getting extremely challenging to treat these infections because of resistance that has occurred to the conventional antifungals, which is attributed to changes in the fungal strains. Keeping in view this issue, more advanced drugs have come into being.

Revolutionizing environmental cleanup: the evolution of MOFs as catalysts for pollution remediation.

The global problem of ecological safety and public health necessitates, the development of new sustainable ideas for pollution remediation. In recent development, metal-organic frameworks (MOF) are the emerging technology with remarkable potential, which have been employed in environmental remediation. MOFs are networks that are created by the coordination of metals or polyanions with ligands and contain organic components that can be customized.

Daily or Twice Daily Treatment with Topical Steroids Results in Similar Responses in Eosinophilic Esophagitis.

Background & Aims: Few data compare topical corticosteroid (tCS) dosing regimens and outcomes. We aimed to compare treatment outcomes in patients with eosinophilic esophagitis (EoE) by once or twice daily dosing regimens.

Methods: We conducted a retrospective cohort study using the UNC EoE Clinicopathologic Database of newly diagnosed patients with EoE treated with a tCS who had a follow-up endoscopy with biopsy.

RiboSeq.Org: an integrated suite of resources for ribosome profiling data analysis and visualization.

Ribosome profiling (Ribo-Seq) has revolutionised our understanding of translation, but the increasing complexity and volume of Ribo-Seq data present challenges for its reuse. Here, we formally introduce RiboSeq.Org, an integrated suite of resources designed to facilitate Ribo-Seq data analysis and visualisation within a web browser.

Green synthesis of NiO and NiO@graphene oxide nanomaterials using leaves: Structural and electrochemical studies.

An eco-friendly synthetic route was developed for the formation of nickel oxide (NiO and NiO) nanoparticles (NPs) by treating Ni(NO).6HO with aqueous/ethanolic extracts of leaves; the same reaction was performed in the presence of graphene oxide (GO) to produce NiO@GO and NiO@GO nanocomposites (NCs), respectively. The NMs were characterized by XRD, FT-IR, SEM, EDX, UV-visible spectroscopy, and TGA-DSC analysis.

Topical Steroids Are Effective and Safe in Patients With Eosinophilic Esophagitis Over a Median of 6.5 Years of Chronic Use.

Goals: To determine long-term efficacy and safety of tCS for treatment of EoE.

Background: Maintenance therapy with topical corticosteroids (tCS) is recommended for eosinophilic esophagitis (EoE), but data for long-term use are still needed.

Study: This retrospective cohort study assessed newly diagnosed patients with EoE who were treated with a tCS and had a follow-up endoscopy with biopsy after at least 5 years.

Nutrition and diet for dry eye disease: Insights toward holistic management.

Dry eye disease (DED) is one of the most common eye problems in the aging population. Hyperosmolarity triggers the immune response in DED and consequently activates the self-perpetuating immune cycle, leading to chronic damage of the ocular surface. This event causes symptoms such as a burning sensation, irritation, redness, photophobia, and blurred vision in DED patients.

Fluorinated Arylarsonate-Containing Polyoxomolybdates: pH-Dependent Formation of Mo vs Mo Species and Their Solution Properties.

We report on the synthesis and structural characterization of six novel arylarsonate-containing polyoxomolybdates with fluorinated-functionalities in the position of the phenyl ring. The reaction of the various arylarsonic acids, RAsOH [ = 4-F-CH (H), 4-FC-CH (H), 4-FCO-CH (H)] with NaMoO·2HO in aqueous pH 3 solution resulted in the heteropoly-6-molybdates [{(4-F-CH)As}MoO(HO)] (), [{(4-FC-CH)As}MoO] () and [{(4-FCO-CH)As}MoO(HO)] (), which were isolated as guanidinium salts. When the reaction was performed in aqueous pH 1 solution the inverted-Keggin type heteropoly-12-molydates [{(4-F-CH)As}MoO] (), [{(4-FC-CH)As}MoO] () and [{(4-FCO-CH)As}MoO] (), were obtained and isolated as sodium salts.

Harnessing the synergistic potential of TiO-CuSe composites for enhanced photocatalytic and antibacterial activities.

With growing environmental concerns, the removal of toxic industrial dyes from wastewater has become a critical global issue. In this study, TiO-CuSe composites were synthesized using a cost-effective and simple chemical method to determine the optimal concentration of CuSe for the efficient degradation of methylene blue (MB) under visible light. The TiO samples exhibited a mix of rutile and anatase phases, while CuSe formed in a hexagonal phase.

Comprehensive analysis of systemic, metabolic, and molecular changes following prospective change to low-carbohydrate diet in adults with type 2 diabetes mellitus in India.

Purpose: South Asians, especially Indians, face higher diabetes-related risks despite lower body mass index (BMI) compared with the White population. Limited research connects low-carbohydrate high-fat (LCHF)/ketogenic diets to metabolic changes in this group. Systematic studies are needed to assess the long-term effects of the diet, such as ocular health.

Safety and Efficacy of Oral Mifepristone for Cervical Ripening and Induction of Labor.

Background Labor induction, a common practice to prevent maternal and fetal complications from prolonged labor, involves stimulating contractions before they begin naturally. This can be achieved through medications, mechanical methods, or surgical interventions. Cervical ripening is crucial for successful delivery.

Tears of blood: an unusual case of haemolacria due to conjunctival vascular malformation successfully managed by embolisation.

A boy in his mid-teens presented with progressively increasing bleeding from the right eye and nostril intermittently over a period of 6 weeks. A complete ophthalmic examination revealed nothing significant. His otorhinological examination and haematological investigations were within normal limits.

Chemotaxis Assay of Bone Marrow-Derived Macrophages.

Immune responses rely on efficient and coordinated migration of immune cells to the site of infection or injury. To reach the site of immunological threat often requires long-range navigation of immune cells through complex tissue and vascular networks. Chemotaxis, cell migration steered by gradients of cell-attractive chemicals that bind sensory receptors, is central to this response.

Advancing breast ultrasound diagnostics through hybrid deep learning models.

Today, doctors rely heavily on medical imaging to identify abnormalities. Proper classification of these abnormalities enables them to take informed actions, leading to early diagnosis and treatment. This paper introduces the "EfficientKNN" model, a novel hybrid deep learning approach that combines the advanced feature extraction capabilities of EfficientNetB3 with the simplicity and effectiveness of the k-Nearest Neighbors (k-NN) algorithm.

Performing Esophageal Biopsies Is Safe During Upper Endoscopy for Food Impaction but Are Underperformed in Certain Populations.

Background: Despite recommendations to perform esophageal biopsies during esophagogastroduodenoscopy (EGD) for esophageal food impaction to evaluate for eosinophilic esophagitis (EoE), endoscopists often forgo biopsies. There are minimal data on the risks of biopsies in this setting.

Aims: To determine the safety of performing biopsies during EGD for food impaction.