Pharmacological and metabolic parameters of [F]flubrobenguane in clinical imaging populations.

Background: Cardiac sympathetic nervous system molecular imaging has demonstrated prognostic value. Compared with meta-[C]hydroxyephedrine, [F]flubrobenguane (FBBG) facilitates reliable estimation of SNS innervation using similar analytical methods and possesses a more convenient physical half-life. The aim of this study was to evaluate pharmacokinetic and metabolic properties of FBBG in target clinical cohorts.