Impact of starting BMI and degree of weight loss on changes in appetite-regulating hormones during diet-induced weight loss.

Objective: The aim of this study was to determine whether the hormone changes following weight loss are proportional to the degree of weight loss and to starting BMI.

Methods: A very low-energy diet was used to achieve 15% weight loss. Fasting and postprandial gut hormones and leptin were measured during a meal test at baseline and at 5% (1%), 10% (2%), and 15% (2.