Publications by authors named "Kira Pahl"
Article Synopsis
- - T-cell receptor (TCR) activation leads to increased calcium (Ca) uptake in mitochondria of human CD4 T-cells, which is critical for T-cell activation and energy production.
- - Effector T-cells show higher levels of Ca and enhanced metabolic activity compared to naive T-cells, influenced by the mitochondrial calcium uniporter (MCU) complex.
- - Reducing MCUa function decreases Ca uptake, mitochondrial respiration, and important T-cell activities like migration and cytokine secretion, suggesting that MCU inhibition could help manage autoimmune diseases.
