Publications by authors named "Kinyu Shon"
Background: Gastroesophageal reflux disease (GERD) is a chronic condition of the digestive tract with limited therapeutic options. Bitter taste receptors (TAS2Rs) and transient receptor potential vanilloid-1 (TRPV1) are implicated in modulating inflammatory responses. Berberine (BBR) and evodiamine (EVO) are known to activate TAS2Rs and TRPV1, respectively.
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- Obesity is linked to gastrointestinal issues, and the visceral adiposity index (VAI) helps assess visceral fat's impact on bowel habits and inflammatory bowel disease (IBD).
- A study using the NHANES dataset analyzed over 10,000 adults, finding a significant negative relationship between higher VAI and chronic constipation, while no clear link was found with IBD.
- The research also revealed a complex relationship between VAI and chronic diarrhea, suggesting moderate visceral fat levels can help prevent chronic constipation and may lower the risk of chronic diarrhea, with healthy sleep contributing positively to bowel health.
Article Synopsis
- Natural products have complex structures and therapeutic significance, making them essential for drug discovery; identifying target proteins of these compounds is necessary for developing new drugs.
- Current methods to identify these targets fall into two categories: labeling methods that modify natural compounds and label-free methods that don't require modifications, each with their pros and cons.
- The review analyzes recent advancements in both approaches and discusses a new method that leverages the natural functions of compounds for quicker target identification, highlighting the need for accurate and reliable identification techniques.
Background: Colorectal adenocarcinoma (COAD) is one of the most common malignancies and angiogenesis is vital to the development of cancer. Here, we explored the roles of angiogenesis-related genes (ARGs) that affect the prognosis of COAD and constructed risk models to assess patient prognosis, immune characteristics, and treatment outcomes.
Methods: We comprehensively characterized the transcriptional and genetic modifications of 48 ARGs in COAD and evaluated the expression patterns.
The correlation between exosomes and the tumor immune microenvironment has been proved to affect tumorigenesis and progression of colon adenocarcinoma (COAD). However, it remained unclear whether exosomes had an impact on the prognostic indications of COAD patients. Expression of exosome-related genes (ERGs) and clinical data were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database.
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