Publications by authors named "Kinue Kuniyasu"
Chromosomal instability (CIN) is commonly seen in cancer cells, and related to tumor progression and poor prognosis. Among the causes of CIN, insufficient correction of erroneous kinetochore (KT)-microtubule (MT) attachments plays pivotal roles in various situations. In this review, we focused on the previously unappreciated role of chromosome oscillation in the correction of erroneous KT-MT attachments, and its relevance to the etiology of CIN.
View Article and Find Full Text PDFThe conserved serine-threonine kinase, Cdc7, plays a crucial role in initiation of DNA replication by facilitating the assembly of an initiation complex. Cdc7 is expressed at a high level and exhibits significant kinase activity not only during S-phase but also during G2/M-phases. A conserved mitotic kinase, Aurora B, is activated during M-phase by association with INCENP, forming the chromosome passenger complex with Borealin and Survivin.
View Article and Find Full Text PDFArticle Synopsis
- Proper chromosome segregation relies on kinetochores attaching to microtubules from opposite sides, and chromosome alignment at the spindle equator is crucial for this process.
- Delays in aligning chromosomes, due to depletion of chromokinesins like Kid and KIF4A, lead to increased rates of chromosome missegregation and lagging chromosomes.
- The study suggests that these delays result in insufficient time for establishing proper bi-orientation, causing chromosomal instability, even in cells that do not show significant mitotic errors.