Endoscopic duodenal-jejunal bypass liner treatment of moderate obstructive sleep apnoea-A pilot study.

We aimed to assess the extent to which people with type 2 diabetes or pre-diabetes, obesity (BMI 30-45 kg/m) and moderate obstructive sleep apnoea (OSA) requiring continuous positive airway pressure ventilation (CPAP) were able to discontinue CPAP following EndoBarrier-related weight loss. We assessed sleep and metabolic parameters before, during and after EndoBarrier in 12 participants with moderate OSA requiring CPAP (75% female, 8/12 [66%] type 2 diabetes, 4/12 [34%] prediabetes, mean ± SD age 52.6 ± 9.

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.

Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.

Design, Setting, And Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin.

Clinical interview assessment of financial capacity in older adults with mild cognitive impairment and Alzheimer's disease.

Objectives: To investigate financial capacity in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) using a clinician interview approach.

Design: Cross-sectional.

Setting: Tertiary care medical center.

Geriatric heart failure, depression, and nursing home admission: an observational study using propensity score analysis.

Objective: Heart failure (HF) and depression are both common in older adults, and the presence of depression is known to worsen HF outcomes. For community-dwelling older adults, admission to a nursing home (NH) is associated with loss of independent living and poor outcomes. The objective of this study was to examine the effect of depression on NH admission for older adults with HF.

The role of psychological factors in dermatologic conditions.

Knowledge about the psychiatric factors affecting dermatologic illness is far from conclusive. Studies in the past decade have strengthened concepts regarding associated psychological factors. Many dermatologic conditions are now considered in the context of genetic predisposition, personality, and biopsychosocial factors.

The role of psychological factors in gastrointestinal conditions. A review pertinent to DSM-IV.

The authors reviewed the literature to assess the relationship between psychological factors and gastrointestinal conditions. The conditions that were found to be more relevant and worthy of future investigation were nonulcerative dyspepsia, inflammatory bowel disease (regional enteritis), and irritable bowel syndrome. The pertinent findings suggest that an important link exists between psychological factors and gastroenterological disorders, which supports the need for modification of the DSM-III-R's diagnostic category, "Psychological Factors Affecting Physical Condition.

Medullary carcinoma of the thyroid before age 2 years.

An 18-month-old infant was evaluated for medullary thyroid carcinoma (MTC) because of a maternal history of the tumor and the presence of characteristic mucosal abnormalities. Although examination of the thyroid gland was normal, RIA of plasma calcitonin reveled elevated basal levels of the hormone and the patient underwent total thyroidectomy at 23 months of age. Histological examination of the tumor was consistent with the diagnosis f MTC, and this diagnosis was confirmed by immunohistology.

An experimental study of the central gustatory pathways in the monkey, Macaca mulatta and Cercopithecus aethiops.

1. The cortex at the base of the central fissure, that is the fronto-parietal operculum, represents primary sensory receptive cortex for gustatory modalities. 2.