WEBINO: A unique neuro-ophthalmological manifestation of the unilateral mid-brain cerebrovascular event.

WEBINO (wall eye intranuclear ophthalmoplegia) is a specific type of neuroophthalmological condition that occurs due to a lesion in the MLF (medial longitudinal fasciculus), which causes unique symptoms characterized by bilateral adduction (inward movement of the eyes) impairment. Still, the abduction (outward movement of the eyes) may be preserved, and nystagmus during abduction is seen along with severe exotropia (outward movement of the eyes). In this case report, we report a 65-year-old male with a sudden onset of double vision, which he noticed while watching television, associated with a certain degree of vision loss and right-sided weakness of the body.

Unmasking herpes encephalitis masquerading as acute psychosis via neuroimaging.

Psychosis is a complex mental health condition that can have a profound impact on individuals and their families. It is characterized by a loss of contact with reality, including delusions, hallucinations, and disorganized thinking. While psychosis is most commonly associated with psychiatric disorders such as schizophrenia, it is crucial to consider other potential causes to ensure accurate diagnosis and appropriate treatment.

Synthesis and biological evaluation of asymmetric indole curcumin analogs as potential anti-inflammatory and antioxidant agents.

Abstract A series of asymmetric indole curcumin analogs were synthesized and evaluated as possible inhibiters of pro-inflammatory enzymes such as COX-2, pro-inflammatory cytokines as TNF-α and IL-6, trypsin and β-glucuronidase. They were also tested for antioxidant activities. The results showed that compounds 5e and 5h were found to be the most potent inhibitors of COX-2 (83.

Synthesis and antioxidant, cytotoxicity and antimicrobial activities of novel curcumin mimics.

Claisen-Schmidt condensation of 3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl)-2,4,5- trimethoxybenzaldehyde 3 and various aromatic, heterocyclic and alicyclic amides of 3- aminoacetophenone 6(a-s) afforded novel curcumin mimics. All the synthesized compounds were characterized by IR, (1)H NMR, Mass spectroscopy and evaluated for antioxidant, cytotoxicity and antimicrobial activity. Out of the 20 compounds screened, compounds 7i, 7l, 7q, and 7n have shown excellent radical scavenging activity, compounds 7o, 7t, 7f, and 7r have shown significant xanthine oxidase inhibition, and compounds 7a, 7k and 7l were found to be potent inhibitors of selected cancer cell lines.

Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents.

A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase. The antioxidant potential was demonstrated using 1,1-diphenyl-2-picryl hydrazine (DPPH) radical scavenging activity. The results of the above studies shows that the compounds synthesized were found to be effective inhibitors of above pro-inflammatory enzymes, and were found to be possess moderate radical scavenging potential.