Cullin 3/with No Lysine [K] Kinase/Ste20/SPS-Related Proline Alanine Rich Kinase Signaling: Impact on NaCl Cotransporter Activity in BP Regulation.

The sodium chloride cotransporter (NCC) fine-tunes Na + balance and indirectly affects the homeostasis of other ions including K + , Mg 2+ , and Ca 2+ . Owing to its effects on Na + balance, BP is significantly affected by alterations in NCC activity. Several factors have been reported to influence the expression and activity of NCC.

lowered serum carcinoembryonic antigen and antigen 125 in 7,12-Dimethylbenz[]anthracene-induced Mammary Carcinogenesis in Female Albino Rats.

Aim: This study is aimed at evaluating the anticancer effect of the aqueous extract of (L.) Sw in 7,12-Dimethlbenz[]anthracene (DMBA) - induced mammary cancer.

Methods: Tumors were induced via a single intraperitoneal injection of DMBA (dissolved in olive oil) at a dose of 80 mg/kg body weight to the test rats and allowed to develop for about four months.

Bio-augmentation and bio-stimulation with kenaf core enhanced bacterial enzyme activities during bio-degradation of petroleum hydrocarbon in polluted soil.

Indigenous micro-organisms often possess the ability to degrade petroleum hydrocarbon (PHC) in polluted soil. However, this process can be improved by supplementing with nutrients or the addition of more potent microbes. In this study, the ability of kenaf-core to stimulate the PHC degradation capability of microbial isolates from PHC polluted soil samples was evaluated.

Drying temperature affects the hypolipidemic, antioxidant, and antihypertensive potential of calyx in rats induced with L-NAME.

The effects of different drying temperatures on the hypolipidemic, antioxidant, and antihypertensive potential of calyx was evaluated. The calyx were dried under different temperature conditions (- 58 °C, 30 °C, 40 °C, and 50 °C), and extracted with a solvent mixture of ethanol and water (1:4 % w/v). To induce hypertension, the rats were administered with 40 mg/kg body weight dose of N-nitro L-arginine methyl-ester (L-NAME), via the intra-gastric route.

calyx protect against oxidative stress and aluminium chloride-induced neurotoxicity in the brain of experimental rats.

We evaluated the antioxidant and neuroprotective potentials of extracts of calyx in Wistar albino male rats injected intraperitoneally with aluminium chloride at a dose of 7 mg/kg/day. Phytochemical screening of calyx show that coumarin glycosides and steroid were absent after drying at 50 C. At 30 C, there were significant (p < 0.

Tolerance, taxonomic and phylogenetic studies of some bacterial isolates involved in bioremediation of crude oil polluted soil in the southern region of Nigeria.

Indigenous bacteria play vital roles in the bioremediation of crude oil polluted soils. The effectiveness of the bioremediation process depends on the tolerance, characteristics and biodiversity of the bacteria isolates. Bacteria strains were isolated from crude-oil polluted sites in different locations in the southern region of Nigeria namely: Azikoro and Otukpoti (Bayelsa state); Ologbo and Benin (Edo State) and non-polluted soil was collected from Ibadan (Oyo state).

Carbohydrate digestive enzyme inhibition, hepatoprotective, antioxidant and antidiabetic benefits of Persea americana.

The medicinal use of Persea americana in the treatment of some diseases like hypertension, diabetes, is often with dearth of supporting scientific proof. Thus, we evaluated its ethnomedicinal benefits for possible scientific justification. Thirty healthy Wistar rats were randomly grouped in fives.

prevents haematological changes, electrolyte imbalance, changes in liver function enzymes and histological alterations in some selected tissues in cadmium chloride-intoxicated rats.

Background: The use of to treat different diseases is popular in the practise of alternative medicine. We investigated the ability of the aqueous extract of to protect against the toxic effects of cadmium.

Methods: Thirty rats used for the experiment were treated as follows; Group 1 no cadmium or extract Group 2-10 mg/kg body weight of cadmium chloride.

protects against oxidative stress, hepatotoxicity and hyperglycaemia in alloxan-induced diabetic rats.

Background: is commonly used in traditional medical practices for the management of diseases like diabetes and its complications. This study seeks to establish a scientific rationale for this practice.

Methods: Thirty Wistar rats were randomly and equally grouped into six.

Relieves Chronic Hepatorenal Injuries in Rats by Altering , , and Expression.

The effectiveness of extracts was compared to that of the standard drug, silymarin, in reducing chronic liver and kidney anomalies. Male albino Wistar rats were grouped in tens. Carbon tetrachloride was dissolved in olive oil (1:4) and administered to specific groups at a dose of 3 mL/kg body weight (bw) twice a week for six weeks.

Evaluation of the haematinic, antioxidant and anti-atherosclerotic potential of in cholesterol-fed experimental rats.

Background: is popularly used in folk medicine in the management of hyperlipidemia and atherosclerosis.

Purpose: To evaluate the anti-atherosclerotic potential of as well as its haematinic and antioxidant potential.

Methods: Seventy-two experimental rats were randomly assigned into 9 groups (I-IX) of 8 rats each.

Sodium retention in nephrotic syndrome is independent of the activation of the membrane-anchored serine protease prostasin (CAP1/PRSS8) and its enzymatic activity.

Experimental nephrotic syndrome leads to activation of the epithelial sodium channel (ENaC) by proteolysis and promotes renal sodium retention. The membrane-anchored serine protease prostasin (CAP1/PRSS8) is expressed in the distal nephron and participates in proteolytic ENaC regulation by serving as a scaffold for other serine proteases. However, it is unknown whether prostasin is also involved in ENaC-mediated sodium retention of experimental nephrotic syndrome.

Proteinuric chronic kidney disease is associated with altered red blood cell lifespan, deformability and metabolism.

Anemia is a common complication of chronic kidney disease, affecting the quality of life of patients. Among various factors, such as iron and erythropoietin deficiency, reduced red blood cell (RBC) lifespan has been implicated in the pathogenesis of anemia. However, mechanistic data on in vivo RBC dysfunction in kidney disease are lacking.

Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na channel in the mouse kidney.

Proteolytic activation of the renal epithelial Na channel (ENaC) involves cleavage events in its α- and γ-subunits and is thought to mediate Na retention in nephrotic syndrome (NS). However, the detection of proteolytically processed ENaC in kidney tissue from nephrotic mice has been elusive so far. We used a refined Western blot technique to reliably discriminate full-length α-ENaC and γ-ENaC and their cleavage products after proteolysis at their proximal and distal cleavage sites (designated from the NH-terminus), respectively.

Combats Oxidative Stress, Protein and Lipid Dyshomeostasis, Inflammation, Hepatic Injury, and Glomerular Blockage in Rats.

, better known as 'pepperfruit', is a medicinal plant consumed in West Africa. possesses strong antioxidant properties and contains uvariopsine, an alkaloid which improves bile secretion and liver function. In the present study, the ethanolic extract of fruits was tested for its ability to alleviate pathophysiological conditions bordering on oxidative stress, including protein and lipid dyshomeostasis, inflammation, and hepatic and glomerular injury.

Evaluation of the phytochemical content, in vitro antioxidant capacity, biochemical and histological effects of fruits in healthy rats.

We estimated the content of specific phytochemicals and in vitro antioxidant properties of the powder, aqueous, and ethanolic extracts of ripe fruits. We also tested the biochemical and histological effects of these fruit extracts on healthy rats. Aqueous and ethanolic extracts were prepared from the powder of ripe fruits, and standard phytochemical methods were used to evaluate its phytochemical content and antioxidant properties.

Assessment of dietary pattern and nutritional status of undergraduate students in a private university in southern Nigeria.

Background: Analysis of dietary patterns gives a more comprehensive impression of the food consumption habits within a population. Poor dietary habits among undergraduate students have been reported as a lifestyle challenge they face while in school. This study was carried out to assess the dietary pattern and nutritional status of undergraduate students in Igbinedion University, Okada.

Evaluation of the glycemic indices of three commonly eaten mixed meals in Okada, Edo State.

People do not generally eat single or individual meals; rather they eat mixed meals, consisting of two or more individual meals. These mixed meals usually have glycemic indices which differ from that of the individual food type. This study was aimed at evaluating the glycemic indices of three commonly consumed mixed meals eaten in Okada; rice and beans (test food 1), rice and plantain (test food 2), beans and plantain (test food 3).

How ageing increases cancer susceptibility: A tale of two opposing yet synergistic views.

It is well known that with increasing age, the risk of acquiring certain age-related diseases - such as diabetes, cancer, cardiovascular disease and neurodegenerative diseases, increases. Several theories have been proposed to explain the reason why ageing leads to higher susceptibility to disease. Over time, many of these theories have been proven wrong.