Publications by authors named "Kinga Virag Gulyas"
Comput Biol Med
April 2024
Article Synopsis
- - Halogenation is a key technique used to modify lead compounds, enhancing their lipophilicity for better membrane permeability and bioavailability.
- - In this study, 19.9% of organohalogen compounds showed increased water solubility compared to their non-halogenated versions, with iodination being the most effective.
- - The presence of groups like amino, hydroxyl, and carboxyl in organohalogens boosts their solubility, while a trifluoromethyl group decreases it; increased polarity and polarizability from halogenation contribute to these changes.
