Patterns of progression in prostate cancer.

Tumour volume was related to metastasis, seminal vesicle invasion, capsule invasion, and histological differentiation in a series of 100 unselected prostates with carcinoma removed at necropsy and 38 removed at radical prostatectomy. All these variables were highly inter-related. In both series, metastases were associated only with tumours larger than 4 ml, a volume attained by only 13% of the necropsy tumours.

Prostatic adenocarcinoma with endometrioid features. Clinical, pathologic, and ultrastructural findings.

Thirteen cases of prostatic adenocarcinoma with endometrioid features were reviewed. The patients were older men (49-81 years) presenting with symptoms of hematuria and urinary obstruction. Each of the tumors displayed exophytic growth into the prostatic urethra, with involvement of the verumontanum.

Effect of prophylactic, low dose cephalexin on fecal and vaginal bacteria.

Effective prophylactic antimicrobial therapy for recurrent urinary tract infections depends upon the creation of minimal antimicrobial resistance in the fecal and vaginal flora. Cephalexin is known to be useful for prophylaxis clinically but substantial resistance has been reported in vaginal and rectal Escherichia coli at doses of 2 gm. per day.