Publications by authors named "Kin Wang Chan"
Article Synopsis
- Nucleosome assembly proteins, like TSPYL2, are vital in chromatin remodeling, which influences gene expression and cell functions.
- Previous research indicates that TSPYL2 negatively regulates cell proliferation by binding to cyclin B.
- In studies with Tspyl2-deficient mice, researchers found that while these mutants appear normal, they struggle with G1 checkpoint activation in response to DNA damage, indicating TSPYL2's role in maintaining cellular stress responses.
Isolation of differentially expressed genes in human heart tissues.
Biochim Biophys Acta
December 2002
Article Synopsis
- The study used RNA arbitrarily primed-PCR (RAP-PCR) to identify genes that show different expression levels in common congenital heart defects (CHD) compared to normal heart samples.
- Three previously unknown genes (hCALO, NP79, SUN2) were identified, alongside known genes (apolipoprotein J, titin, dystrophin, protein kinase C-delta) also expressed in the heart.
- The research confirmed that while hCALO, NP79, and SUN2 were expressed similarly in both TOF and control samples, dystrophin and titin were significantly increased in TOF, highlighting the potential of RAP-PCR in exploring genetic factors in human heart function.