Publications by authors named "Kimura Tetsuya"
Unperceivable electrical noise stimulation has been applied to improve postural control through the enhancement of somatosensory feedback. It has been observed that stimulation with a pink noise (1/f) structure is more effective than stimulation with other noise structures. In addition, the 1/f structure embedded in the postural control system may have a superior effect on postural control stabilization.
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- A study investigated the prescription status of antiplatelet therapy (APT) for patients with non-cardioembolic ischemic stroke (NCIS) and ischemic heart disease (IHD) over three phases from 2015 to 2020.
- Findings showed that while the initial dual antiplatelet therapy (DAPT) rate for NCIS increased over time, many patients stopped taking it after three months, with 25% not receiving any APT afterward.
- In contrast, for IHD patients, the duration of DAPT prescriptions decreased, but the use of single agent therapy (mostly aspirin) increased, highlighting a trend toward shorter DAPT durations in medical care.
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- The study explores the differences in knee biomechanics during walking between males and females with knee osteoarthritis (KOA) to understand why females have a higher prevalence of this condition.
- It identifies that females with KOA exhibit distinct knee movement patterns compared to males, while healthy females show different biomechanics than their male counterparts.
- The findings suggest that the differences in biomechanics may be linked to the presence of KOA, but due to low quality evidence, further research is necessary to draw definitive conclusions.
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- The study evaluates the relationship between frailty and clinical outcomes in elderly Japanese patients with non-valvular atrial fibrillation (NVAF) undergoing catheter ablation (CA) to determine the impact of CA on frailty and assess outcomes based on frailty status.
- A total of 213 elderly patients (average age of 72.8 years) were analyzed, revealing that 12.8% were frail, 53.7% pre-frail, and 33.5% robust, with frail patients experiencing more cardiovascular and bleeding events; however, most did not have AF recurrence after 3 or 6 months post-CA.
- The findings suggest that CA can improve factors related to frailty, indicating that
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- * Out of 32,275 patients studied, 3.5% had GI bleeding, with lower and upper GI bleeding events being 760 and 339 respectively; factors increasing the risk included age over 85, higher body mass index, and use of multiple medications.
- * No significant difference in GI bleeding risk was observed between direct oral anticoagulant (DOAC) users and warfarin users, with a higher mortality rate after upper GI bleeding compared to lower GI bleeding
Brevibacillus thermoruber strain Nabari cells grow as widely spreading dendritic colonies on reasoner's 2A-agar (1.5%) plates at around 55°C but as small motile colonies at 37°C. Motile colonies can be divided into colonies that move in straight or curved lines over long distances (wandering colonies), and colonies that rotate at a fixed location (rotating colonies).
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- The study focused on hepatitis B (HBV) and hepatitis C (HCV) infection and vaccination rates among dental healthcare workers in Oita, Japan, involving 1920 participants.
- Results showed low infection rates: HBsAg positivity at 0.5%, anti-HBs at 39.7%, and anti-HCV at 0.6%, with dentists having significantly higher vaccination and antibody rates than dental staff.
- It concluded that there is a critical need for increased awareness and vaccinations in dental staff, especially elderly workers who may be at greater risk for hepatitis infections.
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- The study explores the relationship between hip capsule thickness and pelvic alignment in female patients with secondary osteoarthritis due to developmental dysplasia of the hip (DDH) in Japan.
- It involved 13 female patients aged 50-79 who underwent total hip arthroplasty, measuring the hip capsule and various pelvic angles with X-rays.
- The findings indicate a moderate negative correlation between hip capsule thickness and the Sharp angle, but no significant links were found with other pelvic measurements, suggesting a complex relationship in the degenerative process for DDH patients.
Background: Regular walking in healthy adults is known to be kinematically stable, but it is unclear how to further kinematically stabilize regular walking. Electromyography biofeedback (EMG-BF) during walking improves walking ability in patients. However, the effect of EMG-BF on walking stability in healthy adults is unknown.
View Article and Find Full Text PDFAims: Atrial fibrillation (AF) and heart failure (HF) often coexist. Older age is strongly associated with stroke, HF, and mortality. The association between coexistence of HF and a risk of clinical outcomes and the effectiveness of anticoagulation therapy including direct oral anticoagulants (DOACs) in elderly patients with AF and HF have not been investigated.
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- * Using administrative claims data, researchers compared lung cancer patients who used RAAS inhibitors with those who did not, finding that RAAS inhibitor users had a significantly lower incidence of PIPN.
- * The findings suggest that RAAS inhibitors, taken at doses typically used for treating high blood pressure, could reduce the risk of PIPN in patients undergoing paclitaxel-based chemotherapy.
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- This study assessed echocardiographic features of left atrial (LA) structure and function in patients aged 75 and older with non-valvular atrial fibrillation (AF) to see how these features related to health outcomes over two years.
- It involved 1,474 elderly patients, analyzing aspects like LA emptying fraction (LAEF) and maximum LA volume index (max. LAVi), revealing that lower LAEF and higher max. LAVi were linked to higher risks of cardiovascular events, heart failure hospitalizations, and overall mortality.
- The findings suggest that elderly patients with poor LA function and larger LA volume need closer monitoring and management for better outcomes.
Prevalent and incident atrial fibrillation are common in patients who undergo transcatheter aortic valve implantation and are associated with impaired postprocedural outcomes, including mortality. We determined predictors of long-term mortality in patients with atrial fibrillation after successful transcatheter aortic valve implantation. The EdoxabaN Versus standard of care and theIr effectS on clinical outcomes in pAtients havinG undergonE Transcatheter Aortic Valve Implantation-Atrial Fibrillation (ENVISAGE-TAVI AF) trial (NCT02943785) was a multicenter, prospective, randomized controlled trial in patients with prevalent or incident atrial fibrillation after successful transcatheter aortic valve implantation who received edoxaban or vitamin K antagonists.
View Article and Find Full Text PDFBackground: This substudy of the Cancer-VTE Registry estimated venous thromboembolism (VTE) incidence and risk factors in pancreatic cancer patients.
Methods: The Cancer-VTE Registry was an observational study that collected VTE data from patients with solid tumors across Japan. We measured baseline VTE prevalence, and at 1-year follow-up, the cumulative incidence of symptomatic and composite VTE (symptomatic VTE and incidental VTE requiring treatment), bleeding, cerebral infarction/transient ischemic attack (TIA)/systemic embolic event (SEE), and all-cause death.
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- The study investigates how coagulation biomarkers relate to clinical outcomes in elderly Japanese patients with atrial fibrillation (AF) treated with either direct oral anticoagulants (DOACs) or warfarin.
- It included patients aged 75 and older, assessing levels of biomarkers like D-dimer and thrombin-antithrombin complex (TAT) alongside their anticoagulant usage.
- The findings indicate that higher biomarker levels correlate with increased risks of cardiovascular events and mortality, with different associations observed between DOAC and warfarin users.
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- A study of over 30,000 elderly Japanese patients with nonvalvular atrial fibrillation (NVAF) found that many had low comprehension of their condition, which was linked to poorer health outcomes.
- Among 1,968 patients assessed for understanding NVAF, 81.9% scored low, which was associated with a higher risk of serious complications like stroke and death.
- Additionally, while 64.9% of the 2,362 patients showed good adherence to anticoagulant therapy, those who were less adherent faced significantly worse prognoses and clinical outcomes.
Objectives: In this study, we investigated the impact of critical care outreach implemented to overcome the problem of rapid response system (RRS) activation. The aim was to evaluate the impact of nurse-led proactive rounding on the rate of adverse events in a hospital setting using an automatic early-warning score system, without a call-activated team.
Methods: This observational study was conducted at a university hospital in Japan.
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- This study analyzed data from over 30,000 elderly Japanese patients with non-valvular atrial fibrillation to investigate the prevalence and impact of low doses of direct oral anticoagulants (DOACs).
- It found that a significant portion of patients were on under- or off-label doses and that factors such as older age, female sex, and certain medical histories were associated with these prescriptions.
- While low DOAC doses didn't increase the risk of stroke or major bleeding, they were linked to a higher rate of overall mortality among patients.
Background: This ANAFIE Registry sub-analysis investigated 2-year outcomes and oral anticoagulant (OAC) use stratified by glycated hemoglobin (HbA1c) levels among Japanese patients aged ≥ 75 years with non-valvular atrial fibrillation (NVAF) with and without clinical diagnosis of diabetes mellitus (DM).
Methods: The ANAFIE Registry was a large-scale multicenter, observational study conducted in Japan; this sub-analysis included patients with baseline HbA1c data at baseline. The main endpoints evaluated (stroke/systemic embolic events [SEE], major bleeding, intracranial hemorrhage, cardiovascular death, all-cause death, and net clinical outcome [a composite of stroke/SEE, major bleeding, and all-cause death]) were stratified by HbA1c levels (< 6.
The benefits of direct oral anticoagulants (DOACs) and warfarin in elderly Japanese patients with non-valvular atrial fibrillation (NVAF) and high home systolic blood pressure (H-SBP) are unclear. This sub-cohort study of the ANAFIE Registry estimated the incidence of clinical outcomes in patients receiving anticoagulant therapy (warfarin and DOACs) stratified by H-SBP levels (<125 mmHg, ≥125-<135 mmHg, ≥135-<145 mmHg and ≥145 mmHg). Of the overall ANAFIE population, 4933 patients who underwent home blood pressure (H-BP) measurements were analyzed; 93% received OACs (DOACs: 3494, 70.
View Article and Find Full Text PDFBackground: Advancing age, decreasing renal function, and atrial fibrillation are strongly associated. Real-world evidence of direct oral anticoagulant (DOAC) use among elderly patients ≥75 years of age with nonvalvular atrial fibrillation and renal dysfunction is limited.
Objectives: This study sought to assess 2-year outcomes and anticoagulant treatment, stratified by renal function.
The left atrial volume index (LAVI) is important for predicting thromboembolism in patients with non-valvular atrial fibrillation (AF), but the utility of LAVI for predicting thromboembolism in patients with both bioprosthetic valve replacement and AF remains unclear. Of 894 patients from a previous multicenter prospective observational registry (BPV-AF Registry), 533 whose LAVI data had been obtained by transthoracic echocardiography were included in this subanalysis. Patients were divided into tertiles (T1-T3) according to LAVI as follows: T1 (n=177), LAVI=21.
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- A study aimed to compare the risks of intracranial hemorrhage (ICH) and ischemic stroke between elderly patients with nonvalvular atrial fibrillation (NVAF) taking direct oral anticoagulants (DOACs) versus those on warfarin.
- The analysis involved over 32,000 patients aged 75 and older, revealing that those on DOACs had a significantly lower incidence of both ischemic strokes and various types of ICH compared to warfarin users during a follow-up period of about 1.88 years.
- Additionally, other characteristics like a history of cerebrovascular disease and persistent NVAF were identified as strong risk factors for ischemic stroke and ICH.