Publications by authors named "Kimone L Fisher"
Elevated IP-10 at the Protein and Gene Level Associates With Pulmonary TB.
Front Cell Infect Microbiol
June 2022
Article Synopsis
- There is a pressing need for better diagnostic tools to differentiate between latent tuberculosis infection (LTBI) and active tuberculosis (TB).
- Recent studies indicate that specific cytokines could act as biomarkers to track the progression of TB disease.
- In research conducted in Durban, South Africa, certain proteins (IL-1RA, IL-6, and IP-10) were found at higher levels in individuals with active TB, suggesting their potential use as indicators for diagnosing TB.
Neutrophils are one of the major early role players in antimycobacterial immunity. Upon infection, neutrophils can undergo NETosis, a cell death characterized by release of neutrophil extracellular traps (NETs). The role of NETosis in TB progression remains poorly characterized.
View Article and Find Full Text PDFThe RV144 HIV-vaccine trial highlighted the importance of envelope-specific non-neutralizing antibody (nNAb) Fc-mediated functions as immune correlates of reduced risk of infection. Since pre-exposure prophylaxis (PrEP) and HIV-vaccines are being used as a combination prevention strategy in at risk populations, the effects of PrEP on nNAb functions both mucosally and systemically remain undefined. Previous animal and human studies demonstrated reduced HIV-specific antibody binding avidity post-HIV seroconversion with PrEP, which in turn may affect antibody functionality.
View Article and Find Full Text PDF