Direct modulation of aberrant brain network connectivity through real-time NeuroFeedback.

The existence of abnormal connectivity patterns between resting state networks in neuropsychiatric disorders, including Autism Spectrum Disorder (ASD), has been well established. Traditional treatment methods in ASD are limited, and do not address the aberrant network structure. Using real-time fMRI neurofeedback, we directly trained three brain nodes in participants with ASD, in which the aberrant connectivity has been shown to correlate with symptom severity.

Intradiscal steroids. A prospective double-blind clinical trial.

A prospective, randomized, double-blind study was performed to evaluate the clinical efficacy of intradiscal steroid injections. Criteria for entrance were one-level internal disc disruption or nonsequestered nuclear prolapse with or without sciatica and a positive pain response on awake discography. Exclusion criteria were multilevel disease, central or lateral stenosis, prior lumbar surgery, or medical disease requiring systemic steroids.

Awake discography. A comparison study with magnetic resonance imaging.

This study was undertaken to determine the correlation between awake discography findings and magnetic resonance imaging in the evaluation of symptomatic lumbar disc disease. The study included 164 consecutive patients who underwent evaluation with discography and magnetic resonance imaging for lumbar disc disease from August 1987 to September 1989. Chronic low-back pain, with or without radicular symptoms, was the presenting complaint in each case.

Intravenous colchicine for low-back pain: a double-blind study.

Colchicine, a drug used for centuries in the treatment of gout, has been reported to be effective for low-back pain due to disc disorders. A prospective, randomized, double-blind study evaluating the therapeutic effect of intravenous colchicine was conducted in a group of patients with low-back pain with symptoms originating less than 6 months previously. Each patient completed a questionnaire and a pain drawing.