Publications by authors named "Kimiyasu Nozaka"
Article Synopsis
- - FOLFOXIRI combined with bevacizumab is an effective first-line treatment for selected patients with untreated metastatic colorectal cancer (mCRC) with specific UGT1A1 genotypes, achieving an overall response rate (ORR) of 63.6%.
- - A study of 47 patients showed favorable outcomes with median treatment times, including 8.1 months for time to treatment failure and 34.4 months for overall survival, although significant adverse events like neutropenia were observed.
- - The results highlight the benefits of this treatment approach in a Japanese patient population, but suggest careful monitoring is needed due to the risk of serious side effects like febrile neutropenia.
Since damage to DNA and other cellular molecules by reactive oxygen species ranks high as a major culprit in the onset and development of colorectal cancer, the aim of the present study is to clarify the role of antioxidant seleonoproteins including glutathione peroxidase (GPx), thioredoxin reductase (TXR) and selenoprotein P (SePP), and the effect of oxidative stress on the progression of colorectal cancer. Expression of 14 oxidative stress-related molecules in both tumorous and non-tumorous tissues in 41 patients was examined by immunohistochemistry and Western blot analysis. Expression levels of proteins modified by 4-hydroxy-2-nonenal (4-HNE), malonyldialdehyde (MDA) and 4-hydroxy-2-hexenal (4-HHE), and the positive rate of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in tumorous tissues were much higher than those in non-tumorous tissues.
View Article and Find Full Text PDFWe report a case of breast cancer with spinal and vertebral lesions. A 49-year-old premenopausal woman with a left breast tumor was admitted to our hospital for acute weakness of the lower limbs and dysuria. She could neither stand nor walk.
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