Publications by authors named "Kiminobu Okayama"
We report two male patients who had a sensory seizure, which evolved into a focal impaired awareness tonic seizure, and after that, focal to bilateral tonic-clonic seizure. The first case, a 20-year-old man had been treated with steroids for anti-myelin oligodendrocyte glycoprotein (MOG) antibody-positive optic neuritis. His seizure started with abnormal sensation in the little finger of the left hand, which spread to the left upper and then to the left lower limb.
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- This study investigated the characteristics of 9 patients with mesial temporal lobe epilepsy who had an amygdalar hamartoma-like lesion without hippocampal sclerosis, focusing on clinical features, EEG results, and neuropsychological assessments.
- Significant findings showed that patients with amygdalar lesions had later seizure onset age and higher rates of fear during seizures compared to those with hippocampal sclerosis. Additionally, they scored higher on IQ and memory tests prior to surgery.
- The results highlight important distinctions between these patient groups, aiding in preoperative evaluations for those suspected of having mesial temporal lobe epilepsy but without obvious hippocampal sclerosis on MRI.
To evaluate changes in the pharmacokinetics of perampanel after discontinuation of carbamazepine. We enrolled 13 patients receiving perampanel who discontinued carbamazepine therapy between June 2016 and December 2018. Data on serum concentrations were obtained from the therapeutic drug monitoring database of the National Epilepsy Center (Shizuoka, Japan).
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