Publications by authors named "Kimiko Morimoto"
Aim: We developed and evaluated the statistical reliability and validity of a family needs scale directly answerable by families in critical care settings.
Methods: In this qualitative study, 39 questions were drafted to capture family needs. These questions were then administered to the families of patients in emergency care settings.
Article Synopsis
- Gastrointestinal stromal tumors (GIST) with exon 11 deletions at codons 557-558 (Δ557-558) show higher growth rates and shorter times without disease compared to other GIST mutations.
- A study of 30 GIST cases found that high-risk malignant GISTs with Δ557-558 experienced significant genomic instability and DNA hypomethylation.
- Whole-genome sequencing revealed that these high-risk GISTs had more structural variations and genetic changes, along with distinct characteristics like chromosomal instability and upregulated gene expressions, setting them apart from lower-risk GISTs.
To inhibit arthritis upstream of inflammatory cytokine release and matrix metalloproteinase (MMP) action, we designed de novo a small-molecule inhibitor of c-Fos/activator protein-1 (AP-1) using three-dimensional (3D) pharmacophore modeling. This model was based on the 3D structure of the basic region-leucine zipper domain of AP-1-DNA complex. Administration of this inhibitor prevented type II collagen-induced arthritis from day 21, before the onset of arthritis, or from day 27, resolved arthritis after its onset.
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