Publications by authors named "Kimihiko Sakamoto"
Article Synopsis
- A study compared the effectiveness of liquid-based endometrial cytology (LBEC) using SurePath™ and suction endometrial tissue biopsy (SETB) for detecting endometrial cancer, with findings published by the Japan Association of Obstetricians and Gynecologists.
- The research involved assessing over 2,000 specimens from five clinics, finding that LBEC had a sensitivity of 92.2% and a negative predictive value of 99.1%, slightly better than SETB's sensitivity of 85.2%.
- The results suggest that LBEC performs just as well as SETB for detecting endometrial malignancies, making it a suitable first-step tool for cancer detection and surveillance in women at risk.
Article Synopsis
- Pegylated liposomal doxorubicin (PLD) has been linked to a rare but concerning condition known as squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients, particularly those with long-term use.
- A study analyzing 114 ovarian cancer patients receiving PLD aimed to determine the prevalence of oral leukoplakia, a precursor to SCCTO, and found this condition in 5.3% of patients, with a median PLD dose at diagnosis of 685 mg/m.
- The findings suggest that a cumulative PLD dose of 400 mg/m or more significantly increases the risk of developing oral leukoplakia, highlighting the need for routine oral monitoring for these
Purpose: Our aim was to evaluate the efficacy and safety of S-1 in heavily pre-treated patients with advanced (FIGO stage IVB) or recurrent cervical cancer.
Methods: The Institutional Review Board of our hospital approved the protocol for this retrospective phase II study. Patients with measurable disease received two oral doses of S-1 (35 mg/m(2)) daily for 4 weeks of a 6-week cycle or 2 weeks of a 3-week cycle.
Objective: To assess the change in disease-specific health-related quality of life and to evaluate patient-perceived satisfaction after radical prostatectomy (RP) or intensity-modulated radiotherapy (IMRT) with androgen deprivation therapy (ADT) for patients with high-risk prostate cancer (PCA) that has been defined by the European Association of Urology guideline.
Methods: Between 2006 and 2010, 150 patients with high-risk PCA who underwent either RP (n = 97) or IMRT with ADT (n = 53) were enrolled in this prospective health-related quality of life study. Disease-specific health-related quality of life at baseline, 3, 6, 12, and 24 months and patient-perceived satisfaction at 12 and 24 months after these treatments were estimated using the Expanded Prostate Cancer Index Composite.
Background: Although recurrent epithelial ovarian cancer (EOC) is generally regarded as an incurable disease, some patients survive more than 5 years after the first recurrence. The aim of this study was to evaluate the clinical features of patients with recurrent EOC who achieve long-term survival.
Methods: We retrospectively reviewed the medical records of 164 patients with recurrent EOC and analyzed the clinical stage, histologic subtype, primary treatment, disease-free interval (DFI), recurrence site, secondary treatment, and overall survival from the time of the first recurrence (R-OS), using the Kaplan-Meier method and the log-rank test.
Natural history and clinicopathologic features of early endometrial carcinoma are not evident. Its knowledge is essential to make up strategies for prevention, early detection, and treatment of endometrial carcinoma. Especially it is important to know pathways of endometrial carcinogenesis and frequency of endometrial carcinomas arising from endometrial hyperplasia.
View Article and Find Full Text PDFObjective: Although postoperative adjuvant chemotherapy is generally recommended for early-stage ovarian cancer, it remains unclear whether adjuvant chemotherapy is also effective for clear cell carcinoma (CCC).
Methods: Seventy-three patients with stage I CCC of the ovary who had undergone complete surgical staging formed the study population (stage IA, 20 patients; stage IC, 53 patients). Survival and multivariate analyses were retrospectively performed to determine the effectiveness of postoperative chemotherapy in these patients.
Background: In the surgical treatment for early-stage cervical carcinoma, it is important to identify preoperatively a low-risk group of patients as candidates for less radical surgery to avoid the morbidity associated with radical hysterectomy. The aim of this study was to evaluate the correlation between tumor diameter measured preoperatively using magnetic resonance imaging (MRI) and pathological prognostic factors in International Federation of Gynecology and Obstetrics (FIGO) stage IB1 cervical carcinoma.
Methods: A total of 125 patients with FIGO stage IB1 cervical cancer were included in this study.
Objective: To evaluate the effectiveness of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy plus postoperative chemotherapy but no radiotherapy for stage IB2-IIB cervical cancer.
Methods: Forty-six consecutive patients with stage IB2-IIB cervical cancer were treated with NAC followed by radical hysterectomy plus postoperative chemotherapy. Median (range) body mass index (BMI) of the patients was 20.