Publications by authors named "Kimia Samadikhah"
The exclusive asialoglycoprotein receptor (ASGR) expression on hepatocytes makes it an attractive target for imaging of the functional liver reserve. Here, we present a set of TRAP-based glycoside trimers and evaluate their imaging properties compared to the gold standard [Tc]Tc-GSA. The click-chemistry-based synthesis approach provided easy access to trimeric low-molecular-weight compounds.
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- The study focuses on a new PET-tracer, [Ga]Ga-NODAGA-TriGalactan, developed to measure functional liver mass, which is critical for liver surgery and transplants.
- The tracer effectively targets the asialoglycoprotein receptor (ASGR) and demonstrated high radiochemical yield, stability, and selective liver uptake in animal studies, outperforming the existing tracer [Tc]Tc-GSA.
- This new compound offers a promising alternative for imaging the functional liver reserve, potentially expanding the application of these imaging techniques in clinical settings.