Albumin-ruthenium catalyst conjugate for bio-orthogonal uncaging of alloc group.

The employment of antibodies as a targeted drug delivery vehicle has proven successful which is exemplified by the emergence of antibody-drug conjugates (ADCs). However, ADCs are not without their shortcomings. Improvements may be made to the ADC platform by decoupling the cytotoxic drug from the delivery vehicle and conjugating an organometallic catalyst in its place.

Total Synthesis of Laucysteinamide A, a Monomeric Congener of Somocystinamide A.

Laucysteinamide A () is a marine natural product isolated from the cyanobacterium and contains structural motifs found in promising cancer drug leads. The first total synthesis of and its analogues was achieved, which also enabled a concise formal synthesis of somocystinamide A (), a dimeric congener of that previously showed extremely potent antiproliferative activities. This work provides further insights on structure-activity relationships in this class of natural products.