Publications by authors named "Kimberly Menendez"
In the United States, the opioid crisis remains a nationwide public health emergency. Narcan laws have increased medical collaboration between emergency medical services (EMS) paramedics and law enforcement officers (LEOs), yet research on joint opioid-response efforts with these first responders remains underexplored. Using a phenomenological approach, this study explores EMS paramedics and LEOs' experiences with joint-response efforts on suspected opioid overdose calls amidst the ongoing opioid crisis.
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- The study analyzed the methylome of chickens vaccinated with an Infectious laryngotracheitis (ILT) vaccine, using MBD-Seq to identify 1,155 differentially methylated regions (DMRs) in their genomes.
- Global DNA methylation levels decreased in the vaccinated birds, resulting in 704 hypomethylated and 451 hypermethylated DMRs, influencing several gene networks related to cancer and immune response.
- The research revealed a negative correlation between DNA methylation changes and the expression of seventeen out of eighteen genes studied, enhancing our understanding of ILT mechanisms.
Article Synopsis
- Infectious laryngotracheitis, caused by gallid herpes virus 1, is a serious disease in chickens with high mortality rates that pose significant economic risks to the poultry industry.
- A study using 15-day-old specific pathogen-free White Leghorn chickens analyzed the effects of vaccination on gene expression, revealing downregulation of myosin and collagen-related genes, which may impact respiratory function.
- The research highlighted the upregulation of various immune-related genes post-vaccination, linking the vaccine's effectiveness to activation of major histocompatibility complex pathways that influence immune responses.
Infectious laryngotracheitis (ILT) is an economically important respiratory disease of poultry that affects the poultry industry worldwide. The disease is caused by gallid herpesvirus I (GaHV-1), a member of the genus Iltovirus, family Herpesviridae, subfamily Alphaherpesvirinae. The current incidence of the disease is heavily influenced by live attenuated vaccines, which have been used extensively since their introduction in the mid-twentieth century.
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