Technetium and Rhenium Schiff Base Compounds for Nuclear Medicine: Syntheses of Rhenium Analogues to Tc-Furifosmin.

Rhenium, the third-row congener of technetium, is often used to develop the macroscopic chemistry of potential Tc diagnostic radiopharmaceuticals. The rhenium analogues to Tc-furifosmin are being developed for potential radiotherapy of multidrug-resistant tumors. Complexes of the form trans-[M(PR)(NO-Schiff base)] are of interest for the potential imaging and treatment of multidrug-resistant tumors.

Pertechnetate-Induced Addition of Sulfide in Small Olefinic Acids: Formation of [TcO(dimercaptosuccinate)] and [TcO(mercaptosuccinate)] Analogues.

Technetium-99 (Tc) is important to the nuclear fuel cycle as a long-lived radionuclide produced in ∼6% fission yield from U or Pu. In its most common chemical form, namely, pertechnetate (TcO), it is environmentally mobile. In situ hydrogen sulfide reduction of pertechnetate has been proposed as a potential method to immobilize environmental TcO that has entered the environment.

Novel rhenium(III, IV, and V) tetradentate N2O2 Schiff base mononuclear and dinuclear complexes.

Reaction of (Bu4N)[ReOCl4] with the tetradentate Schiff base ligand α,α'-[(1,1-dimethylethylene)dinitrilo]di-o-cresol (sal2ibnH2) yields cis-[Re(V)OCl(sal2ibn)], which quickly forms trans-[μ-O(Re(V)O(sal2ibn))2] in solution. The dinuclear complex can also be isolated by the addition of base (Et3N) to the reaction mixture. Conversely, the mononuclear complex can be trapped as cis-[Re(V)O(NCS)(sal2ibn)] by addition of (Bu4N)SCN to the reaction mixture.