Publications by authors named "Kimberly K Obrien"
Article Synopsis
- - The PALISADE study investigated the effects of peanut oral immunotherapy (POIT) using AR101 on peanut-allergic children, demonstrating that it can lead to desensitization and positive immunological changes.
- - Blood samples showed that participants who successfully desensitized had lower basophil sensitivity and T-cell reactivity to peanuts compared to those who reacted during the challenge test, indicating a significant shift in their immune response.
- - The results support the idea that AR101 therapy reshapes peanut-reactive T cells, enhancing clinical outcomes while suggesting the therapy's potential as a future treatment option for peanut allergies.
Complement component C4 (C4) is a highly variable complement pathway gene situated ∼500 kb from DRB1 and DQB1, the genes most strongly associated with many autoimmune diseases. Variations in C4 copy number (CN), length, and isotype create a highly diverse gene cluster in which insertion of an endogenous retrovirus in the ninth intron of C4, termed HERV-K(C4), is a notable component. We investigated the relationship between C4 variation/CN and type 1 diabetes.
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