Objectives/hypothesis: In gerbils in which tinnitus was induced by salicylate, neurons in the dorsal raphe nucleus were activated. Since about half the neurons in this region are serotonergic, this indicates that serotonin (5-HT) might play a role in the mechanisms of central tinnitus. The goal of this study was to determine if serotonergic neurons are activated during salicylate-induced tinnitus.
View Article and Find Full Text PDFHypothesis: Serotonergic neurons are activated during salicylate-induced tinnitus and modulate the cochlea during tinnitus.
Background: During salicylate-induced tinnitus in the gerbil, neurons in the dorsal raphe nucleus were activated. Because approximately half of the neurons in this region are serotonergic, this indicates that serotonin (5-HT) might play a role in the mechanisms of central tinnitus.