Publications by authors named "Kimberly Judson-Kremer"
Carcinogenesis
February 2003
Article Synopsis
- Researchers studied how normal human mammary epithelial cells (HME87) respond to the carcinogen benzo[a]pyrene diol epoxide (BPDE), finding that after 24 hours of treatment, the cells didn’t undergo typical cell cycle arrest or apoptosis despite a 50% reduction in cell number.
- Gene expression analysis using the RAGE technique revealed that while some genes related to DNA damage response were activated early, the p21-WAF1 gene, which prevents cells from moving from G(1) to S phase, only increased after 24 hours.
- The study highlighted significant changes in gene expression, including transcription factors like ATF3 and E2A, and noted that BPDE treatment led to early
