Publications by authors named "Kimberly J Ellis"
J Infect Dis
December 2022
Article Synopsis
- A phase 1b study evaluated the safety and immune response of an intranasal M2-deficient single replication (M2SR) influenza vaccine in adults aged 18-49.
- Subjects received two doses of the vaccine, with results showing significant increases in neutralizing antibodies after higher doses; 80.6% demonstrated a response after the 109 TCID50 dose.
- The vaccine was well tolerated and elicited both mucosal and cellular immune responses, suggesting its potential effectiveness against drifted H3N2 influenza strains.
