Publications by authors named "Kimberly Hayward"
Article Synopsis
- The evaluation of chemicals using early-life stage zebrafish has shown significant variation in reported phenotypes among researchers, highlighting the need for consistent terminology and data standards in toxicological studies.
- By applying standardized phenotype terminology via the Zebrafish Phenotype Ontology, a recent study found that data consistency improved and ambiguity decreased when researchers analyzed zebrafish larvae for malformations.
- A larger-scale study is needed to confirm these findings, but establishing a common data standard is recommended to enhance agreement and repeatability across different laboratories, paving the way for a zebrafish phenotype atlas.
Populations of plants and animals, including humans, living in close proximity to abandoned uranium mine sites are vulnerable to uranium exposure through drainage into nearby waterways, soil accumulation, and blowing dust from surface soils. Little is known about how the environmental impact of uranium exposure alters the health of human populations in proximity to mine sites, so we used developmental zebrafish (Danio rerio) to investigate uranium toxicity. Fish are a sensitive target for modeling uranium toxicity, and previous studies report altered reproductive capacity, enhanced DNA damage, and gene expression changes in fish exposed to uranium.
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