Publications by authors named "Kimberly East"
Transplant Cell Ther
September 2021
Article Synopsis
- Successful allogeneic hematopoietic stem cell transplantation (alloHSCT) requires a specific dose of total nucleated cells (TNCs), with 2 × 10 TNCs per kg of recipient weight as the minimum for effective engraftment.
- An algorithm that takes into account baseline donor characteristics can help in predicting TNC concentrations, which vary significantly across donors.
- Analysis of donor data revealed that factors like higher body mass index, younger age, male sex, and certain preharvest blood counts strongly correlate with higher TNC concentrations, and two predictive models, LASSO and OLS, showed the best fit for this prediction.
