Publications by authors named "Kimberly Chaffin"
Article Synopsis
- - The study investigates the chemical stability of different transvenous lead materials, focusing on Optim leads, by analyzing the molar mass of extracted pacing and defibrillator leads from Emory University Hospitals.
- - Researchers examined 70 extracted leads, comparing the chemical degradation of insulation materials like poly(ether)urethane and Optim over various implant durations, with findings showing Optim's molar mass decreased to 40% after 10 years.
- - The reduction in molar mass for Optim indicates potential premature insulation defects, which correlates with higher rates of electrical malfunctions observed in these cardiac leads.
Intervertebral disc (IVD) degeneration is a common pathological condition associated with low back pain. Recent evidence suggests that mesenchymal signaling cells (MSCs) promote IVD regeneration, but underlying mechanisms remain poorly defined. One postulated mechanism is via modulation of macrophage phenotypes.
View Article and Find Full Text PDFSegmented polyurethane multiblock polymers containing polydimethylsiloxane and polyether soft segments form tough and easily processed thermoplastic elastomers (PDMS-urethanes). Two commercially available examples, PurSil 35 (denoted as P35) and Elast-Eon E2A (denoted as E2A), were evaluated for abrasion and fatigue resistance after immersion in 85 °C buffered water for up to 80 weeks. We previously reported that water exposure in these experiments resulted in a molar mass reduction, where the kinetics of the hydrolysis reaction is supported by a straight forward Arrhenius analysis over a range of accelerated temperatures (37-85 °C).
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