Publications by authors named "Kimberly Bodaar"
Article Synopsis
- The article discusses subgaleal hematomas as a rarely considered cause of head swelling in older children, primarily linked to excessive hair styling techniques.
- It presents two cases from Juliana Children's Hospital where patients experienced head swelling and headaches, which were identified as subgaleal hematomas due to significant hair traction.
- The conclusion emphasizes the need for thorough patient evaluations to consider hair traction as a potential cause of head swelling, aiming to reduce unnecessary tests and treatments.
Resistance to mitochondrial apoptosis predicts inferior treatment outcomes in patients with diverse tumor types, including T-cell acute lymphoblastic leukemia (T-ALL). However, the genetic basis for variability in this mitochondrial apoptotic phenotype is poorly understood, preventing its rational therapeutic targeting. Using BH3 profiling and exon sequencing analysis of childhood T-ALL clinical specimens, we found that mitochondrial apoptosis resistance was most strongly associated with activating mutations of JAK3.
View Article and Find Full Text PDFThe tendency of mitochondria to undergo or resist BCL2-controlled apoptosis (so-called mitochondrial priming) is a powerful predictor of response to cytotoxic chemotherapy. Fully exploiting this finding will require unraveling the molecular genetics underlying phenotypic variability in mitochondrial priming. Here, we report that mitochondrial apoptosis resistance in T cell acute lymphoblastic leukemia (T-ALL) is mediated by inactivation of polycomb repressive complex 2 (PRC2).
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