Publications by authors named "Kimberly Barbet"
Background: Using primary airway epithelial cells (AEC) is essential to mimic more closely different types and stages of lung disease in humans while reducing or even replacing animal experiments. Access to lung tissue remains limited because these samples are generally obtained from patients who undergo lung transplantation for end-stage lung disease or thoracic surgery for (mostly) lung cancer. We investigated whether forceps or cryo biopsies are a viable alternative source of AEC compared to the conventional technique.
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- The study investigates the natural compound diphyllin's effectiveness against SARS-CoV-2, the virus responsible for COVID-19, particularly against various variants like Alpha, Beta, Delta, and Omicron.
- Results show that diphyllin inhibits the virus's entry into cells in a dose-dependent manner by disrupting critical processes required for viral entry.
- The research highlights diphyllin's potential as a dual-action antiviral agent by targeting both endosomal and cell surface pathways involved in SARS-CoV-2 entry.
Background: It has previously been shown that the Helicobacter pylori (H. pylori)-derived molecule vacuolating cytotoxin A (VacA) could be suitable for the treatment of allergic airway disease. The therapeutic activity of the protein, which acts through modulation of dendritic cells (DC) and regulatory T cells (Tregs), was demonstrated in murine short-term acute models.
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