Cutaneous manifestations of vasculitis.

Objectives: To discuss the clinical features, diagnostic evaluation, and treatment options for cutaneous vasculitis.

Methods: The literature in the PubMed database was reviewed regarding the presentation, pathophysiology, clinical workup, and treatment of cutaneous vasculitis.

Results: Available classification criteria of vasculitis are based on histopathologic criteria or clinicohistologic features.

Between a rock and a hard place: disclosing medical errors.

Background: Healthcare-related errors cause patient morbidity and mortality. Despite fear of reprimand, laboratory personnel have a professional obligation to rapidly report major medical errors when they are identified. Well-defined protocols regarding how and when to disclose a suspected error by a colleague do not exist.

Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinoma.

It is often difficult to distinguish hepatocellular adenoma (HCA) from well-differentiated hepatocellular carcinoma (WDHCC) when limited tissue from a needle biopsy is evaluated. The aim of this study was to identify gene expression patterns that can distinguish HCA from WDHCC, with the ultimate goal of discovering novel diagnostic markers. Gene expression profile analysis was performed using Affymetrix U133Plus2 GeneChip microarrays on RNA isolated from frozen tissue of 6 HCA and 8 WDHCC specimens.

Aortic intimal sarcoma detected on helical CT.

Aortic intimal sarcomas are rare among the already uncommon primary aortic neoplasms. Due to a low index of suspicion, characteristic radiographic and clinical findings are sometimes misattributed and the diagnosis is not made until autopsy. We describe the helical CT findings of a patient with an advanced aortic intimal sarcoma, intraluminal and extraluminal disease, and extensive metastases.