Neighbor effect: penumbra-dose exposed neighbor cells contribute to the enhanced survival of high-dose targeted cells.

Purpose: In the last decade, new types of 'bystander effect' have been suggested by multiple research groups and have been challenged by others. In this study, we explored a new type of bystander effect, which has been defined in previous studies as the enhancement of the survival of high-dose targeted cells due to the penumbra-dose exposed neighbor cells. Intensity-modulated radiation therapy, which is the most widely used treatment modality, generates local regions of gradient doses between targeted and shielded cells throughout the treatment volume; therefore, we were urged to ascertain whether the new type of effect is real and to suggest a revised treatment planning.

A practical alpha particle irradiator for studying internal alpha particle exposure.

An alpha particle irradiator has been built in the Radiation Bioengineering Laboratory at Seoul National University (SNU) to investigate the cellular responses to alpha emissions from radon and the progeny. This irradiator is designed to have the energy of alpha particles entering target cells similar to that of alpha emissions from the radon progeny Po-218 and Po-214 residing in the human respiratory tract. For the SNU alpha particle irradiator, an irradiation system is equipped with cell dishes of 4µm thick Mylar bottom and a special setup of cells on slide for gamma-H2AX assay.

Chitin from Cuttlebone Activates Inflammatory Cells to Enhance the Cell Migration.

Our previous report showed that the extract from cuttlebone (CB) had wound healing effect in burned lesion of rat and the extract was identified as chitin by HPLS analysis. We herein investigated the morphology in CB extract using scanning electron microscope (SEM). Chitin was used as a control.

Eosinophilic pleuritis due to sparganum: a case report.

Sparganosis is a rare parasitic disease caused by migrating plerocercoid tapeworm larva of the genus Spirometra. Infection in humans is mainly caused by the ingestion of raw or inadequately cooked flesh of infected frogs, snakes, and chickens. Here, we report a rare case of a 45-year-old man who was admitted to our hospital with left lower chest pain.

Single pleural relapse of a nasal-type extranodal natural killer/t-cell lymphoma: a case report.

A nasal-type extranodal natural killer/T-cell lymphoma is considered an aggressive form of non-Hodgkin's lymphoma, with approximately half of all patients relapsing during the follow-up period, and most relapses occurring within the first 2 years of remission. Here we report an unusual case of a 42-year-old man who experienced recurrence in single pleura after 8 years of remission.

The role of the ethylacetate fraction from hydnocarpi semen in acute inflammation in vitro model.

We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated for their wound healing activity by using in vitro acute inflammation model. GC and GC/MS analysis shows that the main constituents in EtOAc fraction are chaulmoogric acid, hydnocarpic acid, and gorlic acid.

Insight into the unique oxidation chemistry of elemental mercury by chlorine-containing species: experiment and simulation.

This work investigated the oxidation chemistry of elemental mercury (Hg(0)) by chlorine-containing species produced indirectly through the gas-to-solid phase reaction between NO(x) gases and NaClO(2) powder (NaClO(2)(s)), where both experiment and simulation results were compared to clarify which species are responsible for the oxidation of Hg(0). At first, we introduced 30 ppm of NO(2) into the pack-bed reactor containing NaClO(2)(s) to produce OClO species and then injected NO and Hg(0) (260 microg/Nm(3)) to Mixer, where the concentration of NO was varied up to 180 ppm and the reaction temperature was set to 130 degrees C. We observed for the first time that the degree of Hg(0) oxidation is completely controlled by the introduced concentration of NO: for example, the oxidation efficiency of Hg(0) is drastically increased to become 100% at near 7 ppm NO, but further increasing NO concentration results in the oxidation efficiency of Hg(0) being gradually decreased.

Reaction pathways of NO oxidation by sodium chlorite powder.

NO oxidation is an important prerequisite step to assist selective catalytic reduction at low temperatures (< 250 degrees C). If sodium chlorite powder (NaClO2(s)) can oxidize NO to NO2, the injection of NaClO2(s) can be simply adapted to NO oxidation. Therefore, we explored the reaction pathways of NO oxidation by NaClO2(s).

Neurologic sequela of hydrogen sulfide poisoning.

A 25-year-old man, a field operator in a petroleum refinery was found unconscious. He was exposed to hydrogen sulfide and presented with Glasgow Coma Score of 5, severe hypoxemia on arterial blood gas analysis, normal chest radiography, and normal blood pressure. On hospital day 7, his mental state became clear, and neurologic examination showed quadriparesis, profound spasticity, increased tendon reflexes, abnormal Babinski response, and bradykinesia.

Effect of leukotactin-1 on the protection in vivo of myeloid progenitor cells against cytotoxic chemotherapeutics.

Leukotactin-1 (Lkn-1) is a human CC chemokine that induces chemotaxis of neutrophils, monocytes, eosinophils, and lymphocytes and suppresses colony formation of myeloid progenitor cells in vitro. Present studies evaluated the myeloprotective capabilities of Lkn-1 in vivo against Ara-C and 5-fluorouracil (5-FU). The effect of Lkn-1 on myelopoiesis was first assessed in vivo by injecting recombinant Lkn-1 in C3H/HeJ mice.