Publications by authors named "Kim Young Woo"

Background: Within the tumor microenvironment (TME), the association of B lymphocytes (B cells) with prognosis and therapy response in gastric cancer (GC) remains poorly characterized. We investigated the predictive and prognostic value of B cells, including their spatial organization within the TME, in one of the largest multi-cohort studies to date.

Methods: Using CD20 immunohistochemistry, we evaluated B cell density in resection specimens from 977 patients with resectable GC across three cohorts, including the randomized phase III Korean CLASSIC trial.

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Saccharomyces boulardii is a probiotic that can alleviate inflammation in the gut. In this study, a novel surface display system was developed by employing two different single-chain variable fragments (scFvs) against human tumor necrosis factor α as model anti-inflammatory proteins. We first optimized the expression levels of the scFvs by selecting strong constitutive promoters, of which expression cassettes were integrated into the S.

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Background/objectives: has been demonstrated to exert biological effects on several cell types. This study investigated the efficacy of the edible ethanol extract of (EERH) against human colorectal carcinoma cell line (HCT116) cells.

Materials/methods: HCT116 cells were cultured with different concentrations of EERH (0, 400, 600, 800, and 1,000 µg/mL) in Dulbecco's modified Eagle medium.

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This study investigates zone melting (ZM) as an innovative method for recycling 7000 series aluminum alloy scraps, a byproduct of computer numerical control (CNC) machining in smartphone production. Traditional fluxing methods are ineffective at removing Zn, a key alloying element. Vacuum atmospheric ZM utilizes the evaporation of Zn and Mg impurities and solidification segregation to concentrate elemental impurities within the melt, facilitating their efficient removal.

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Introduction: Randomised controlled trials (RCTs) with surgical interventions frequently lack a framework to ensure surgical quality. We aimed to investigate surgical quality assurance (SQA) in oesophagogastric oncology trials and to develop a translatable framework of strategies to overcome challenges in the design and implementation of SQA.

Methods: Seventy-one peer-nominated, international, expert trial stakeholders included surgeons; oncologists; trial managers and trial methodologists.

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Objective: The laparoscopic approach for locally advanced gastric cancer has recently been adopted based on the results of several randomized controlled trials (RCTs). However, findings from RCTs have not been examined at the national level. This study aimed to investigate the external validity of the Korean Laparoscopic Gastrointestinal Surgery Study-02 (KLASS-02) trial involving 13 tertiary hospitals, using data from the Korean Gastric Cancer Association (KGCA)-led nationwide survey involving 68 tertiary or general hospitals.

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White organic light-emitting diodes (OLEDs) represent a significant technology in the display industry for the achievement of full color. However, sophisticated technologies are required for white light emission. In this paper, we developed a simple white light-emitting display device using a quantum-dot (QD) film and a greenish-blue OLED.

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Introduction: Network pharmacology has gained significant traction as a tool for identifying the mechanisms and therapeutic effects of herbal medicines. However, despite the usefulness of these approaches, their diversity underscores the critical need for a systematic evaluation to ensure consistency and reliability.

Objectives: We aimed to evaluate the network pharmacological analyses, focusing on identifying the mechanisms and therapeutic effects of herbal medicines.

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Postmenopausal osteoporosis is a major global health concern, particularly affecting aging women, and necessitates innovative treatment options. Herbal medicine, with its multi-compound, multi-target characteristics, offers a promising approach for complex diseases. In this study, we applied multiscale network and random walk-based analyses to identify candidate herbs and their active ingredients for postmenopausal osteoporosis, focusing on their underlying mechanisms.

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The femoral artery is the preferred access route for neurointerventions. The transfemoral approach (TFA) offers advantages such as a large diameter and easy access. However, it also entails disadvantages such as patient discomfort and high risk of complications.

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The 3-helix is a crucial secondary structure in proteins, playing an essential role in various protein-protein interactions, yet stabilizing it in biologically relevant peptides remains challenging. In this study, we investigated the potential of 4-atom hydrocarbon staples to stabilize 3-helices in peptides. Using ring-closing metathesis, we demonstrated that the staple's configuration is critical for both the stabilization and screw sense control of 3-helices.

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This study explores e-scooter riders' risky behaviour and motivation based on survey, observation, and interview studies. 192 responses from an online survey showed that e-scooter riders' behaviours are categorised into errors, violations, defensive behaviour, and proactive safety behaviour. Statistical analysis revealed significant differences in riding behaviour depending on riders' characteristics and usage patterns.

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Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease, with few effective treatments besides alcohol abstinence. Angelicae Gigantis Radix (AG), Glycyrrhizae Radix et Rhizoma (GR), Paeoniae Radix (PR), and Zizyphi Fructus (ZF) are traditional herbs used to treat various ailments, including liver diseases. While several studies have reported the beneficial effects of GR on ALD, the effects of AG, PR, and ZF remain underexplored.

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Article Synopsis
  • Korea's healthcare system emphasizes early and proactive treatment for stroke to enhance patient outcomes, as indicated by a study on stroke epidemiology and outcomes.
  • Data from over 86,000 acute stroke patients were analyzed, revealing that ischemic stroke was the most prevalent type, followed by intracerebral and subarachnoid hemorrhages.
  • The study showed that 49.6% of patients arrived at hospitals within 4.5 hours of symptom onset, leading to good functional outcomes in 58.3% of patients, with variations in prognosis based on the type of stroke.
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  • Precision medicine requires reliable tools for personalized therapy, and this study tested the feasibility of the single patient classifier (SPC) test for stage II-III gastric cancer patients.
  • A multicenter study with 237 patients showed that 99.5% of SPC test results were delivered on time before choosing postoperative treatments, with a median delivery time of 4 days.
  • The results indicated significant differences in 3-year disease-free survival rates among the risk groups identified by the SPC test, supporting its potential for improving treatment decisions.
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Manual contouring of organs at risk (OAR) is time-consuming and subject to inter-observer variability. AI-based auto-contouring is proposed as a solution to these problems if it can produce clinically acceptable results. This study investigated the performance of multiple AI-based auto-contouring systems in different OAR segmentations.

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  • The study aimed to compare the long-term outcomes of laparoscopic pylorus preserving gastrectomy (LPPG) and laparoscopic distal gastrectomy (LDG) for treating early gastric cancer (EGC) in a multicenter randomized controlled trial with 256 patients.
  • Results showed no significant difference in the incidence of dumping syndrome after one year (13.2% for LPPG vs. 15.8% for LDG), but LPPG had lower rates of gallstone formation and better preservation of hemoglobin and serum protein levels.
  • While LPPG had more instances of reflux esophagitis and delayed gastric emptying, overall survival and quality of life after three years were similar between the two
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This study comprehensively explored the helix-stabilizing effects of amine-bearing hydrocarbon cross-links (ABXs), revealing their context-dependent nature influenced by various structural parameters. Notably, we identified a 9-atom ABX as a robust helix stabilizer, showcasing versatile synthetic adaptability while preserving peptide water solubility. Future investigations are imperative to fully exploit this system's potential and enrich our chemical toolkit for designing innovative peptide-based biomolecules.

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  • - Sentinel node navigation (SNN) is effective for stomach-preserving surgery in early gastric cancer but has technical challenges in practice.
  • - A study analyzed data from the SENORITA trial, evaluating the effectiveness of regional lymphadenectomy without SNN on 237 patients, focusing on lymph node metastasis in relation to tumor location.
  • - Results indicated that while SNN showed higher sensitivity and negative predictive values for detecting metastasis compared to regional lymphadenectomy, completely omitting SNN in surgery was deemed insufficient and not recommended.
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  • Network pharmacology is a valuable method for understanding how natural products, like herbs, can offer therapeutic benefits, yet there's a gap in thoroughly evaluating these network approaches.
  • The study identifies a widely used herb to scrutinize the effectiveness of network methodologies, focusing on its active components and roles in chronic diseases, particularly in liver cirrhosis and gastrointestinal cancers.
  • Results indicate that the proposed multiscale interaction-based method is effective in discovering active ingredients and mechanisms while establishing a solid framework for further research in natural product therapies.
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  • The phase III PRODIGY study found that neoadjuvant chemotherapy with docetaxel, oxaliplatin, and S-1 (DOS), followed by surgery and adjuvant S-1, improved progression-free survival (PFS) in patients with resectable locally advanced gastric cancer (LAGC).
  • Long-term follow-up showed that the group receiving neoadjuvant DOS (CSC) had significantly better overall survival (OS) rates compared to those who underwent surgery followed by adjuvant S-1 (SC), with 8-year OS rates of 63.0% vs. 55.1%.
  • The results suggest that neoadjuvant DOS chemotherapy should be considered a standard treatment
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  • In Asia, adjuvant chemotherapy combined with nivolumab post-gastrectomy is being assessed for effectiveness and safety in treating pathological stage III gastric or gastro-oesophageal junction cancer.
  • The ATTRACTION-5 trial involved a randomized, double-blind study across 96 hospitals in East Asia, enrolling patients aged 20-80 with confirmed stage IIIA-C cancer following specific surgeries.
  • Patients were divided into two groups to receive either nivolumab with chemotherapy or a placebo with chemotherapy, with the main focus on measuring relapse-free survival and analyzing safety data.
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Background: This study aimed to assess the outcomes of conservative management in patients with thoracolumbar fractures classified with a Thoracolumbar Injury Classification and Severity (TLICS) score of 4 or 5, and to analyze initial imaging findings and clinical risk factors associated with treatment failure.

Methods: In this retrospective analysis, patients with thoracolumbar fractures and a TLICS score of 4 or 5, determined through MRI from January 2017 to December 2020, were included. Patients undergoing conservative treatment were categorized into two groups: Group 1 (treatment success) and Group 2 (treatment failure), based on initial and 6-month follow-up outcomes.

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Article Synopsis
  • The SENORITA trial aimed to evaluate the quality of life (QoL) and nutritional outcomes of patients undergoing two types of surgeries: laparoscopic sentinel node navigation surgery (LSNNS) and laparoscopic standard gastrectomy (LSG).
  • The objective was to compare long-term QoL and nutritional outcomes between patients who had stomach-preserving surgery and those who underwent standard gastrectomy, as well as to identify factors affecting QoL in the stomach-preserving group.
  • The analysis included 194 patients who underwent stomach-preserving surgery and 257 who had standard gastrectomy, with findings indicating that the stomach-preserving group experienced better QoL scores three months post-surgery.
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