Efficacy of dextrose prolotherapy on temporomandibular disorder: a retrospective study.

Objectives: Dextrose prolotherapy is one of the most promising minimally invasive interventions for temporomandibular disorder (TMD), particularly in refractory cases where other conservative treatments have failed. The purpose of this study was to demonstrate the efficacy of a new treatment, temporomandibular joint (TMJ) prolotherapy, in patients with TMD to alleviate symptoms.

Materials And Methods: A retrospective analysis was conducted on TMD patients with chronic pain who did not respond to conventional treatments.

TGFβ2-Driven Ferritin Degradation and Subsequent Ferroptosis Underlie Salivary Gland Dysfunction in Postmenopausal Conditions.

Despite the high incidence of dry mouth in postmenopausal women, its underlying mechanisms and therapeutic interventions remain underexplored. Using ovariectomized (OVX) mouse models, here this study identifies ferroptosis, an iron-dependent regulated cell death, as a central mechanism driving postmenopausal salivary gland (SG) dysfunction. In the OVX-SGs, TGFβ signaling pathway is enhanced with the aberrant TGFβ2 expression in SG mesenchymal cells.

Visible light-activated dye-sensitized TiO antibacterial film: A novel strategy for enhancing food safety and quality.

Antibacterial packaging holds promise in addressing food spoilage by inactivating bacteria, but current antimicrobial packaging solutions face challenges like depletion of antibacterials and concerns of antibiotic abuse. In response to these limitations of existing packaging materials, we developed a novel antibacterial packaging film by incorporating titanium dioxide (TiO)- tetra(4-carboxyphenyl) porphyrin (TcPP) conjugates into cellulose nanofibrils (CNF) films. Unlike conventional antimicrobial packaging, this film harnesses visible light energy to excite electrons from TcPP to TiO, generating reactive oxygen species (ROS) that inactivate bacteria without relying on antibiotics.

3D-printed shadow masks for micro-patterned electrodes.

Microfabrication is critical to the advancement of lab-on-chip devices by enabling the creation of high-precision, complex electrode structures. Traditional photolithography, commonly used to fabricate micro-patterned electrodes, involves complex and multi-step processes that can be costly and time-consuming. In this research, we present a method using 3D-printed shadow masks for electrode fabrication, offering a simpler, cost-effective alternative to traditional methods.

Inter- and Intraspecific Competition in Invasive and Co-Occurring Weedy Plant Species.

While invasive success of alien plant species is often attributed to their superior competitive abilities, it is also suggested that competitive ability depends on the target species of competition and resource availability. In addition, it remains unclear whether invaders and co-occurring plants in the introduced area exhibit distinctive inter- and intraspecific competitive intensities. This study aimed to evaluate the competitive ability of a successful invader, , through a combination of field surveys and a growth chamber experiment.

Clinical Significance of Lumbar Puncture in Children with First Febrile Seizures.

Objectives: To evaluate the need for lumbar puncture (LP) in children aged 6 to 60 months experiencing their first febrile seizure, regardless of seizure type, and to determine if LP is particularly beneficial for those under 12 months old.

Materials & Methods: In this retrospective study, data from 253 children who presented with first febrile seizure were analyzed. All patients in this study underwent LP and were divided into two groups based on their cerebrospinal fluid (CSF) results: non-pleocytosis and pleocytosis.

First molecular evidence of bovine hemoplasmas in houseflies (Musca domestica).

Background: Hemoplasma infections in cattle are caused by Mycoplasma wenyonii and Candidatus Mycoplasma haemobos and induce asymptomatic or chronic infections but occasionally lead to life-threatening hemolytic anemia. Despite the global distribution of bovine hemoplasmas, information regarding their transmission vectors and prevalence is still lacking in the Republic of Korea. Therefore, this study aims to investigate the infection rate of bovine hemoplasma in cattle and houseflies and to assess the risk factors associated with hemoplasma infection in cattle.

Bacteriophages targeting Enterococcus faecalis enhance the therapeutic efficacy of levodopa in an MPTP-induced Parkinson's disease mouse model with E. faecalis gut colonization.

Despite the intensive research on gut microbiome-associated diseases over the past 20 years, pharmacological methods for effectively eliminating pathobionts remain unsatisfactory. This study investigated the therapeutic potential of bacteriophages against Enterococcus faecalis, in which bacterial tyrosine decarboxylase (TDC) converts orally administered levodopa (L-DOPA) to dopamine, in an MPTP mouse model of Parkinson's disease (PD). E.

Deciphering melanophagy: role of the PTK2-ITCH-MLANA-OPTN cascade on melanophagy in melanocytes.

Melanosomes play a pivotal role in skin color and photoprotection. In contrast to the well-elucidated pathway of melanosome biogenesis, the process of melanosome degradation, referred to as melanophagy, is largely unexplored. Previously, we discovered that 3,4,5-trimethoxycinnamate thymol ester (TCTE) effectively inhibits skin pigmentation by activating melanophagy.

Routine Elastic Staining Helps Detection of Vascular Invasion in Colorectal Cancer: A Comprehensive Analysis of T3 or Higher Tumors Without Lymph Node Metastasis.

Background/aim: Vascular invasion (VI) in colorectal carcinoma (CRC) is an independent prognostic feature and a high-risk indicator for adjuvant chemotherapy in stage II CRC. This study evaluated the effect of elastic staining on VI detection.

Patients And Methods: The VI was assessed using elastic staining in 154 patients with CRC.

Association of ATM and ARID1A in gastric carcinoma.

Background: The ataxia telangiectasia mutated (ATM) gene is involved in the repair of double-stranded DNA breaks and a component of the DNA damage repair pathway. Tumors with mutations or low expression of both ARID1A and ATM exhibit increased numbers of tumor-infiltrating lymphocytes and a favorable prognosis. However, the relationship between ATM and ARID1A in gastric carcinoma (GC) is unclear.

Age Does Not Impact Cancer Specific Mortality: From Sub-Distributional and Cause-Specific Hazard Analysis in RCC Patients Undergoing Radical Nephrectomy and Thrombectomy.

Objective: To assess the impact of age on cancer-specific mortality (CSM) and other-cause mortality (OCM) in patients undergoing radical nephrectomy with thrombectomy (RNTx) for renal cell carcinoma (RCC) with venous thrombus.

Patients And Methods: We retrospectively analyzed 196 patients who underwent RNTx for RCC with venous thrombus between 1990 and 2018 at a single tertiary referral center. Patients were categorized into three age groups: <60, 60-69, and ≥70 years.

Antibacterial, Antibiofilm, and Anti-inflammatory Effects of a Novel Thrombin-Derived Peptide in Sepsis Models: Insights into Underlying Mechanisms.

We developed two short helical antimicrobial peptides, HVF18-a3 and its d-enantiomer, HVF18-a3-d, derived from the thrombin C-terminal peptide HVF18. These peptides exhibit potent antimicrobial activity against various bacteria by compromising both the outer and inner membranes, with low hemolytic activity. They are stable in the presence of physiological salts and human serum, exhibiting a low potential for developing drug resistance and excellent antibiofilm activity against Gram-negative bacteria.

The Role of Education and English Proficiency in Cognitive Health Among Older Refugee Populations in the United States.

Cognitive impairment is pronounced in forcibly displaced populations. This study examined how education and English proficiency are associated with cognitive difficulties between refugee and non-refugee older immigrants. Analyses assessed the moderating effect of refugee status on the association of education and English proficiency with cognitive difficulty.

Enhancing Passive Radiative Cooling Films with Hollow Yttrium-Oxide Spheres Insights from FDTD Simulation.

Passive daytime radiative cooling (PDRC) presents a promising avenue for efficient thermal management without relying on electrical power. In this study, the potential of integrating Hollow Yttrium-Oxide Spheres (HYSs) within a Polydimethylsiloxane (PDMS) matrix to enhance PDRC is investigated. Through a combination of experimental characterization and computational analysis, the optical properties and radiative cooling performance of PDMS films embedded with HYSs are evaluated.

Correction: Nucleic acid detection with single-base specificity integrating isothermal amplification and light-up aptamer probes.

Correction for 'Nucleic acid detection with single-base specificity integrating isothermal amplification and light-up aptamer probes' by Jaekyun Baek , , 2024, https://doi.org/10.1039/D4NR01638F.