Genotypic, phenotypic, and proteomic characterization of Candida glabrata during sequential fluconazole exposure.

Aim: Candida glabrata is a major pathogen in humans known to be intrinsically resistant to fluconazole. However, genotypic, phenotypic, and proteomic changes associated with reduced susceptibility to fluconazole are not properly understood. The aim of this study was to observe specific phenotypic, chromosomal, and proteomic alterations in a Candida glabrata strain sequentially exposed to fluconazole.

The willingness of general dental practitioners to treat people with handicapping conditions: the Hong Kong experience.

A study was carried out to assess the willingness of general dental practitioners in Hong Kong to treat patients with handicaps. A questionnaire and practitioner scale were developed and circulated to 400 general dental practitioners of which 250 responded giving a response rate of 62.5%.