Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping.

Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities and their links to various clinical complications, especially long COVID, remains a challenge. In this study, we performed unsupervised subtyping of longitudinal multi-omics immunophenotyping in over 1,000 hospitalized patients, identifying two critical subtypes linked to mortality or mechanical ventilation with prolonged hospital stay and three severe subtypes associated with timely acute recovery.

The PFAS-Tox Database: A systematic evidence map of health studies on 29 per- and polyfluoroalkyl substances.

Background: PFAS (per-and polyfluoroalkyl substances) are a large class of synthetic chemicals widely used in consumer products and industrial processes. The scientific literature on PFAS has increased dramatically in the last decade. Many stakeholders, including regulators, scientists, non-governmental organizations, and concerned individuals could benefit from an efficient way to access the health and toxicological literature related to PFAS.

An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction.

In the United States, onshore oil and gas extraction operations generate an estimated 900 billion gallons of produced water annually, making it the largest waste stream associated with upstream development of petroleum hydrocarbons. Management and disposal practices of produced water vary from deep well injection to reuse of produced water in agricultural settings. However, there is relatively little information with regard to the chemical or toxicological characteristics of produced water.

Annual Incidence and Phenotypic Presentation of IBD in Southern New Zealand: An 18-Year Epidemiological Analysis.

Background: The aim of this study was to describe the incidence of inflammatory bowel disease (IBD) and changes in demographic and phenotypic disease presentation in Otago, New Zealand.

Methods: This study was conducted at Dunedin Hospital and the study period was 1996-2013. Otago residents diagnosed with IBD were identified retrospectively from hospital lists using ICD-10 codes.

Exploring the endocrine activity of air pollutants associated with unconventional oil and gas extraction.

Background: In the last decade unconventional oil and gas (UOG) extraction has rapidly proliferated throughout the United States (US) and the world. This occurred largely because of the development of directional drilling and hydraulic fracturing which allows access to fossil fuels from geologic formations that were previously not cost effective to pursue. This process is known to use greater than 1,000 chemicals such as solvents, surfactants, detergents, and biocides.

Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs.

Aim: To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol (FODMAP) diet on irritable bowel syndrome (IBS) symptoms and quality of life (QoL).

Methods: Participants with IBS (Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline.

Polycyclic aromatic hydrocarbons and female reproductive health: A scoping review.

Polycyclic aromatic hydrocarbons (PAHs) are a class of common persistent environmental pollutants found in water, air, soil, and plants and can be released by natural sources. However, the majority of atmospheric PAHs are from vehicular emissions, coal-burning plants, and the production and use of petroleum-derived substances. Exposure to PAHs has been implicated in cancer and other diseases, including reproductive disorders.

Inspiring Collaboration: The Legacy of Theo Colborn's Transdisciplinary Research on Fracking.

This article describes Dr Theo Colborn's legacy of inspiring complementary and synergistic environmental health research and advocacy. Colborn, a founder of endocrine disruption research, also stimulated study of hydraulic fracturing (fracking). In 2014, the United States led the world in oil and gas production, with fifteen million Americans living within one mile of an oil or gas well.

Bacterial colonization of wristwatches worn by health care personnel.

We examined bacterial colonization of wristwatches worn by 100 health care personnel in a community-teaching hospital. Seventy-eight percent of the wristwatches were colonized with bacterial skin flora, with only 1 of the 100 watches growing a potential pathogen, Staphylococcus aureus. Watches are unlikely to be sources of health-care associated pathogens.