Publications by authors named "Kim Minger"
Platelet Function: Meloxicam Intravenous in Whole Blood Samples From Healthy Volunteers.
Clin Pharmacol Drug Dev
October 2020
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective treatments for pain but may induce bleeding events due to platelet dysfunction associated with inhibition of cyclooxygenase (COX)-1 impairing thromboxane production. An intravenous nanocrystal formulation of meloxicam, a COX-2 preferential nonsteroidal anti-inflammatory drug, is under development for the treatment of moderate to severe pain. This single-center ex vivo study evaluated the effect of meloxicam intravenous and ketorolac on platelet function in whole blood samples from healthy volunteers.
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- The study investigates the safety of 2-hour preoperative clear liquid fasting in overweight/obese children undergoing day surgery, hypothesizing that BMI and fasting duration wouldn't affect gastric fluid volume (GFV) or pH.
- Data collected from 1,000 pediatric surgery patients aged 2-12 included demographics, medical history, and gastric content measurements after intubation to assess GFV.
- Results showed that 14% of participants were overweight and 13.3% were obese, but GFV was similar across all BMI groups when adjusted for ideal body weight, indicating that fasting may not pose a significant risk for these patients.