Publications by authors named "Kim Melanie Kaiser"
Article Synopsis
- Longitudinal studies of the innate immune system are crucial for understanding how COVID-19 progresses and affects the body.
- In a study involving 205 patients, researchers characterized natural killer (NK) cells and found that severe COVID-19 is linked with high levels of interferon (IFN)-α and decreased NK cell function.
- The findings suggest that distinct immune responses (IFN-α in severe cases and tumor necrosis factor in moderate cases) contribute to varying disease severities and that ongoing NK cell dysfunction may lead to complications like fibrotic lung disease.
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time.
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