Publications by authors named "Kim L Dinh"
At the air/buffer solution interface the kinetics of adsorption of amyloid beta peptide, Abeta(1-42), whose bulk concentration (submicromolar) is more than 2 orders of magnitude lower than that typically used in other in vitro aggregation studies, has been studied using a Langmuir-Blodgett trough. The pressure-time curves exhibit a lag phase, wherein the surface pressure essentially remains at zero, and a rising phase, corresponding to the Abeta adsorption at the interface. The duration of the lag phase was found to be highly dependent on both the Abeta bulk concentration and the solution temperature.
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- The lack of crystal structures for amyloid-beta (Abeta) complexes with metals like Cu(II), Fe(II), and Zn(II) has made their characterization challenging.
- Through the use of fluorescence and electron paramagnetic resonance (EPR) spectroscopies, this study explores how Cu(II) interacts with Abeta, revealing that Cu(II) can be reduced to Cu(I) and both forms of the complex are stable.
- The research indicates that fluorescence quenching associated with Abeta-Cu(II) can be restored upon reduction to Cu(I), and highlights the role of tyrosine in determining the properties of the metal complex, providing insights into the coordination and oxidation state of copper in relation to Abeta.