Potential Mediators between Fibromyalgia and C-Reactive protein: Results from a Large U.S. Community Survey.

Background: Fibromyalgia, a potentially debilitating chronic pain syndrome of unknown etiology, may be characterized by inflammation. In this study, we investigated the relation of FMS to serum C-reactive protein (CRP) in a large population of adults (18+) and investigated the influence of other factors on this relationship, including BMI, comorbidities, as well as mood and sleep disturbance.

Methods: Participants were 52,535 Ohio Valley residents (Fibromyalgia n = 1125).