Publications by authors named "Kim Jhingook"
Immune checkpoint blockades are actively adopted in diverse cancer types including metastatic melanoma and lung cancer. Despite of durable response in 20-30% of patients, we still lack molecular markers that could predict the patient responses reliably before treatment. Here we present a composite model for predicting anti-PD-1 response based on tumor mutation burden (TMB) and transcriptome sequencing data of 85 lung adenocarcinoma (LUAD) patients who received anti-PD-(L)1 treatment.
View Article and Find Full Text PDFPurpose: To develop an MRI-based radiomics model to predict high-risk pathologic features for lung adenocarcinoma: micropapillary and solid pattern (MPsol), spread through air space (STAS), and poorly differentiated patterns.
Materials And Methods: As a prospective study, we screened clinical N0 lung cancer patients who were surgical candidates and had undergone both 18F-fluorodeoxyglucose (FDG) positron emission tomography-CT (PET/CT) and chest CT from August 2018 to January 2020. We recruited patients meeting our proposed imaging criteria indicating high-risk, that is, poorer prognosis of lung adenocarcinoma, using CT and FDG PET/CT.
Article Synopsis
- Occult lymph node metastasis (OLNM) is common in patients with resectable non-small cell lung cancer (NSCLC), despite following established diagnostic guidelines.
- The study evaluated the risk of OLNM based on specific radiologic characteristics of primary tumors as seen on CT scans in a retrospective analysis of 2042 NSCLC patients.
- Findings revealed that certain tumor features, such as endobronchial location, significantly increased the risk of OLNM, while others, like heterogeneous ground-glass opacity, had a lower risk, helping clinicians better determine the need for invasive nodal staging.
Article Synopsis
- The study evaluated the effectiveness and safety of adjuvant pembrolizumab in patients with stage IIIA/N2 non-small cell lung cancer (NSCLC) who underwent prior neoadjuvant chemoradiation therapy and complete surgical resection.
- Findings showed a median disease-free survival (DFS) of 22.4 months and a 5-year DFS rate of 29%, indicating pembrolizumab may help control the disease long-term for some patients.
- Despite some patients experiencing tumor recurrence, no new safety concerns were observed, suggesting that pembrolizumab could be a viable treatment option post-surgery for specific NSCLC patients.
Article Synopsis
- The study examines the risks of complications following major lung surgery after neoadjuvant concurrent chemoradiation therapy in patients with stage IIIA-N2 non-small cell lung cancer.
- It reveals that patients over 70 years old, those with low body mass index, and those undergoing pneumonectomy face significantly higher rates of morbidity and mortality post-surgery.
- The findings suggest that alternative treatments may be more suitable for high-risk patients, particularly the elderly or those with poorer lung function, rather than pursuing surgical options.
Article Synopsis
- Recent research highlights the importance of novel transcriptional factor-based molecular subtypes in predicting outcomes for small-cell lung cancer (SCLC) patients through in-depth analysis of multi-omics data combined with immunohistochemistry (IHC).
- The study involved a comprehensive examination of data from 427 SCLC patients, focusing on mutation profiles, gene expression, and inflammation signatures, revealing distinct molecular subtypes and their clinical outcomes.
- Findings showed significant differences in survival rates among subtypes, with the ASCL1 subtype exhibiting the most favorable overall survival, and inflamed tumors being more responsive to immunotherapy compared to non-inflamed tumors.
Article Synopsis
- * Out of 810 patients, 19.6% experienced PPCs, with those in the low lung function groups having a significantly higher relative risk (RR) for developing these complications compared to those with better lung function.
- * The findings suggest that poor preoperative lung function increases the risk of PPCs after esophagectomy, especially when both FEV and DLco levels are low.
Article Synopsis
- Lung cancer diagnostic guidelines recommend invasive mediastinal nodal staging (IMNS), but its effectiveness on survival in non-small cell lung cancer (NSCLC) patients without lymph node metastasis (rN0) remains unclear.
- A study compared long-term survival rates between NSCLC patients who underwent IMNS and those who did not, using data from the Samsung Medical Centre from 2008 to 2016.
- Results showed no significant survival difference; both groups had similar 5-year overall survival rates (73.9% for IMNS vs. 71.7% for non-IMNS) and recurrence-free survival rates, despite a 7.2% incidence of unexpected metastasis in the IMNS group.
Article Synopsis
- This study reviews cases of patients who underwent contralateral lung resection following a pneumonectomy over a 26-year period, providing insights into the challenges and outcomes of this procedure.
- A total of 13 patients participated, with a median age of 57 and a variety of surgical interventions performed, mainly wedge resections.
- The results indicate that complications were common but manageable, showing that this type of surgery can be safely performed in well-selected patients.
Article Synopsis
- The study investigates the expression of PD-L1, a biomarker for immunotherapy, in lung adenocarcinoma and how it relates to a new grading system for tumors.
- In a cohort of 1,233 patients, PD-L1 positivity was found to increase with tumor grade: 7% in G1, 23.5% in G2, and 63% in G3 tumors.
- PD-L1 was linked to worse patient outcomes, being an independent risk factor for recurrence and death in G2 tumors, but not significantly in G3 tumors.
Article Synopsis
- This study evaluated treatment outcomes for patients with recurrent stage I non-small cell lung cancer (NSCLC) who previously had part of their lung removed (sublobar resection) and later underwent completion lobectomy (CL).
- Out of 36 patients analyzed, those who underwent CL had significantly better overall survival (OS) and post-recurrence survival (PRS) compared to those who received non-surgical treatments or no treatment.
- The research concludes that while CL is a complex but safe procedure, further studies with larger groups and longer follow-up are needed to validate these findings.
Article Synopsis
- Accurate diagnostic criteria for tumor invasion are crucial for precise pT staging in lung adenocarcinoma, and recent IASLC criteria have not yet been clinically validated.
- A study of 1,295 patients from Samsung Medical Center showed that the revised pT staging led to a 22% downstaging and better predictions for recurrence-free survival and metastasis than the original pT staging.
- The findings suggest that the IASLC criteria align better with clinicopathologic factors and improve prognostic assessment, highlighting the need for further research on its impact on treatment decisions.
Background: Invasive mucinous adenocarcinoma (IMA) is distinct from non-mucinous adenocarcinoma, but studies on recurrent IMA are scarce. Thus, this study aimed to evaluate the recurrence patterns of IMA and the role of pulmonary local therapy (LT) in resectable pulmonary recurrence of IMA.
Methods: The study reviewed 403 patients with surgically resected IMA between 1998 and 2018.
Article Synopsis
- The study developed and validated a new testing method called the Allele-Discriminating Priming System (ADPS) for detecting EGFR mutations in lung cancer, claiming to improve sensitivity of traditional tests by up to 100 times and achieving a detection limit of 0.01%.
- In a comparative analysis involving 189 tumor samples, the ADPS kit showed a high agreement rate (97.4%) with the established cobas EGFR Mutation Test v2, with a notable 100% negative agreement, indicating its reliability.
- The ADPS test identified EGFR mutations in 50.3% of cases, and due to its increased sensitivity, it allowed for potential treatment adjustments
Objectives: The aim of the study was to evaluate the clinical outcomes of patients with lung cancer in whom left ventricular ejection fraction (LVEF) was reduced.
Methods: A total of 9814 patients with lung cancer who underwent pulmonary resection from 2010 to 2018 were included for the study. Fifty-six (0.
Article Synopsis
- The study examined molecular subtypes of small cell lung cancer (SCLC) using whole sections of tumor samples to better understand their clinical and prognostic significance.
- Researchers identified four main subtypes: SCLC-A (54.8%), SCLC-N (31.5%), SCLC-P (6.8%), and triple-negative SCLC (6.8%), with SCLC-N being significantly enriched in combined SCLCs.
- YAP1 expression was linked to poor prognosis and increased recurrence rates, particularly in SCLC cases with non-small cell-like morphology, highlighting its role in tumor heterogeneity and phenotypic changes rather than as a standalone subtype.
Purpose: Guidelines recommend that non-small cell lung cancer (NSCLC) patients with suspected hilar lymph node (LN) metastases should undergo invasive mediastinal LN staging prior to surgical treatment via endosonography. We evaluated the diagnostic performance of endosonography for detecting occult mediastinal metastases (OMM) and determined the factors associated with OMM in NSCLC patients with radiological N1.
Materials And Methods: Patients with confirmed primary NSCLC with radiological N1 who underwent endosonography for nodal staging assessment from January 2013 to December 2019 were retrospectively analyzed.
Aims: The prognostic role of EGFR mutations remains controversial. We aimed to evaluate the prognostic role of EGFR mutation in consideration of the IASLC histological grade in patients with resected early-stage lung adenocarcinoma.
Methods And Results: A total of 3297 patients with stages I-IIA resected lung adenocarcinoma who had had EGFR mutation tests between January 2014 and December 2019 at the Samsung Medical Center, Seoul, Korea were included.
Background: Pulmonary resection surgery causes severe postoperative pain and usually requires opioid-based analgesia, particularly in the early postoperative period. However, the administration of large amounts of opioids is associated with various adverse events. We hypothesized that patients who underwent pulmonary resection under an enhanced recovery after surgery (ERAS) program consumed fewer opioids than patients who received conventional treatment.
View Article and Find Full Text PDFBackground: This study analyzed and described the clinical characteristics and surgical outcomes of diaphragmatic hernia (DH) repair according to the operative approach.
Methods: After excluding cases with a combined approach and hiatal hernias, we analyzed 26 patients who underwent DH repair between 1994 and 2018. The baseline and perioperative characteristics of the thoracic approach group and the abdominal approach group were described and analyzed.
Pulmonary lymphangitic carcinomatosis (PLC) is associated with a poor prognosis in patients with non-small cell lung cancer (NSCLC). We sought to determine prognostic value of pretherapeutic fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in NSCLC with radiologically diagnosed PLC. We retrospectively reviewed 50 NSCLC patients with radiologically diagnosed PLC.
View Article and Find Full Text PDFBackground: The prevalence of lymph node (LN) metastasis in small-sized lung cancer varies depending on the tumor size and proportion of ground-glass opacity. We investigated occult LN metastasis and prognosis in patients with small-sized non-small cell lung cancer (NSCLC), mainly focusing on the pure-solid tumor.
Methods: We retrospectively reviewed patients with ≤2-cm clinical N0 NSCLC who underwent lung resection with curative intent from 2003 to 2017.