Drug treatment-related factors of inadequate seizure control.

To optimize seizure control it is important to identify modifiable factors. We conducted a case-control study to explore to what extent drug treatment-related factors are associated with seizures. Eighty-six patients with epilepsy were evaluated: 45 cases (recently experienced a seizure) and 41 controls (seizure-free for at least 2 months).

Influence of chemical structure on hypersensitivity reactions induced by antiepileptic drugs: the role of the aromatic ring.

Objective: Antiepileptic drugs (AEDs) can cause various 'idiosyncratic' hypersensitivity reactions, i.e. the mechanism by which AEDs induce hypersensitivity is unknown.

Changes in medication associated with epilepsy-related hospitalisation: a case-crossover study.

Aim: To assess the association between changes in medication and epilepsy-related hospitalisation.

Methods: Data were obtained from the PHARMO Record Linkage System (Jan 1998 to Dec 2002). We conducted a case-crossover study among patients with a first epilepsy-related hospital admission who had continuously used at least one antiepileptic drug (AED) during a 28-week period before admission.

Risk of aplastic anemia in patients using antiepileptic drugs.

Purpose: To assess the association between exposure to antiepileptic drugs (AEDs) and the occurrence of aplastic anemia.

Methods: A retrospective case-control study was conducted using data from the U.K.