Publications by authors named "Kim A Young"

: Although the risk of serious bleeding following peritoneal dialysis catheter insertion is low, pericannular bleeding can increase the risk of catheter-related infections and reduce catheter survival. We aimed to analyze the risk factors for bleeding complications during peritoneal dialysis catheter insertion and assess whether temporary preemptive hemodialysis before catheterization can reduce bleeding and improve catheter survival. : We retrospectively analyzed bleeding complications and catheter survival in patients who underwent temporary hemodialysis prior to peritoneal dialysis catheter insertion.

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Objective: There is insufficient evidence to determine the effectiveness of treating allergic rhinitis with a patch laser affix to the skin as opposed to direct intranasal irradiation of the nasal mucosa. We aimed to evaluate the effect of the microneedle patch laser with multiple wavelengths in an allergic rhinitis (AR) mouse model and its underlying mechanism.

Methods: The microneedle patch laser was attached to the skin above the mouse's nasal cavity, transmitting light to the nasal mucosa.

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  • The study aimed to investigate whether switching gadolinium-based contrast agents (GBCAs) can help reduce the recurrence of acute adverse drug reactions (ADRs) associated with their use during MRI exams.
  • From nearly 239,000 MRI exams between January 2016 and December 2021, 1,042 cases of acute ADRs were identified, with follow-up evaluations showing a recurrence rate of 31.9% among patients who experienced ADRs.
  • Results indicated that patients who switched to different GBCAs had a significantly lower recurrence of ADRs (14.3%) compared to those who remained on the same agent (36.9%), suggesting that changing
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Epithelial-to-mesenchymal transition (EMT) is considered as one of the senescence processes; reportedly, antisenescence therapies effectively reduce EMT. Some models have shown antisenescence effects with the use of sodium-glucose cotransporter 2 (SGLT2) inhibitor. Therefore, our study investigated the antisenescence effects of empagliflozin as an SGLT2 inhibitor in a peritoneal fibrosis model and their impact on EMT inhibition.

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Matricellular proteins are integral non-structural components of the extracellular matrix. They serve as essential modulators of immunometabolism and tissue homeostasis, playing critical roles in physiological and pathological conditions. These extracellular matrix proteins including thrombospondins, osteopontin, tenascins, the secreted protein acidic and rich in cysteine (SPARC) family, the Cyr61, CTGF, NOV (CCN) family, and fibulins have multi-faceted functions in regulating immune cell functions, metabolic pathways, and tissue homeostasis.

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Purpose: To determine whether switching to contrast media based on the sharing of N-(2,3-dihydroxypropyl) carbamoyl side chain reduces the recurrence of iodinated contrast media (ICM)-associated adverse drug reactions (ADRs).

Materials And Methods: This single-center retrospective study included 2133 consecutive patients (mean age ± SD, 56.1 ± 11.

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Ventricular septal defect (VSD) is a common congenital heart disease. However, consensus on the utility of echocardiography in predicting spontaneous closure (SC) of VSD remains lacking. This study aimed to identify and validate significant predictors of SC through a predictive scoring system.

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Background: Pulsta valve is increasingly used for percutaneous pulmonary valve implantation (PPVI) in patients with a large native right ventricular outflow tract (RVOT). This study aims to elucidate the outcomes of Pulsta valve implantation within the native RVOT and assess its adaptability to various native main pulmonary artery (PA) anatomies.

Methods: A multicenter retrospective study included 182 patients with moderate to severe pulmonary regurgitation in the native RVOT who underwent PPVI with Pulsta valves® between February 2016 and August 2023 at five Korean and Taiwanese tertiary referral centers.

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Understanding the physical properties of organic-inorganic hybrid [NH(CH)]ZnCl is necessary for its potential application in batteries and fuel cells due to its environmentally-friendly, and highly stable character. Here, we determine its overall properties in detail, such as its orthorhombic crystal structure, and phase transition temperatures associated with five different phases. Structural geometry was studied by the chemical shifts caused by the local field around H.

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Background: Over the last decade, extracorporeal membrane oxygenation (ECMO) use in critically ill children has increased and is associated with favorable outcomes. Our study aims to evaluate the current status of pediatric ECMO in Korea, with a specific focus on its volume and changes in survival rates based on diagnostic indications.

Methods: This multicenter study retrospectively analyzed the indications and outcomes of pediatric ECMO over 10 years in patients at 14 hospitals in Korea from January 2012 to December 2021.

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A 3-year-old boy with Glenn physiology exhibited refractory heart failure with reduced ejection fraction. To improve the patient's oxygen saturation, he underwent ventricular assist device (VAD) implantation with concomitant Fontan completion. The extracardiac conduit Fontan operation was performed with a 4-mm fenestration.

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  • Sulfide-based all-solid-state batteries (ASSBs) are gaining popularity due to their high energy density and safety, but interfacial resistance from side-reactions can hinder performance.
  • A study reveals that using a Li SnP S (LSnPS) cathode buffer layer significantly stabilizes the interface between the cathode and sulfide-based solid electrolytes, improving electrochemical properties.
  • The LSnPS-coated cathode shows impressive performance with a capacity of 192 mAh/g and around 75% retention after 500 cycles, suggesting a promising approach for more efficient and eco-friendly ASSB commercialization.
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Background: Previous studies have shown that an elevated prehospital National Early Warning Score (preNEWS) is associated with increased levels of adverse outcomes in patients with trauma. However, whether preNEWS is a predictor of massive transfusion (MT) in patients with trauma is currently unknown. This study investigated the accuracy of preNEWS in predicting MT and hospital mortality among trauma patients.

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Polyamic acid (PAA) was synthesized using the diamine monomer ,'-[2,2'-bis(trifluoromethyl)-4,4'-biphenylene]bis(4-aminobenzamide) and dianhydride monomer 4,4'-oxydiphthalic anhydride. Colorless and transparent poly(amide imide) (CPAI) hybrid films were prepared multi-step thermal imidization of PAA in which various contents of nano-filler were dispersed. The CPAI hybrid films were prepared by dispersing organoclay STN, which was obtained by organically modifying hectorite, in CPAI by solution intercalation with various contents ranging from 1 to 7 wt%.

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  • Jak3 is identified as a promising target for treating chronic inflammatory skin diseases like psoriasis and alopecia, with potential roles in tissue repair and sebaceous gland (SG) development.
  • In a study using ICR mouse skin, selective Jak3 inhibitors were applied to examine their effects on SG remodeling after skin wounds.
  • Results showed that Jak3 inhibition reduced the area and volume of SG remodeling without affecting the number of sebocytes, suggesting that targeting Jak3 could be beneficial for skin conditions related to SG hyperplasia.
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Inadequate oral care and poor oral health in older adults are known to increase the risk of dementia. Dementia patients residing in long-term care facilities are especially vulnerable to oral diseases due to their care-resistant behavior. This study aimed to investigate the effects of a 7-day oral care program based on an aroma solution in 58 dementia patients (29 each in the experimental and control groups) admitted to a long-term care hospital in South Korea.

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We aimed to report the incidence and severity of nonionic low-osmolar iodine contrast medium (ICM)-related adverse drug reactions (ADRs) in the Republic of Korea, by analyzing data from our single tertiary institution and published Korean reports, and to determine whether there is a difference in the incidence of ICM-related ADR by ICM generics. A total of 1,161,419 consecutive contrast-enhanced computed tomography (CT) examinations between January 2016 and December 2021 at Asan Medical Center were included. A systematic search of the literature investigating the incidence of ICM-related ADR in the Republic of Korea published up to December 31, 2021 was performed.

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The current study aimed to investigate the possibility of rapid and accurate diagnoses of Panic disorder (PD) and Major depressive disorder (MDD) using machine learning. The support vector machine method was applied to 2-channel EEG signals from the frontal lobes (Fp1 and Fp2) of 149 participants to classify PD and MDD patients from healthy individuals using non-linear measures as features. We found significantly lower correlation dimension and Lempel-Ziv complexity in PD patients and MDD patients in the left hemisphere compared to healthy subjects at rest.

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Background: The endangered longhorn beetle Callipogon (Eoxenus) relictus, which was designated as a natural monument since 1968 in Korea is still attracting public concern because of its extraordinary body size. Although mitochondrial genome data of this species was reported using Korean individual in 2017, start codon of cox1 is controversial and the secondary structures of transfer RNAs have not been illustrated.

Objective: To report complete mitochondrial genome of Callipogon (Eoxenus) relictus from Chinese breed.

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  • * The DfIV virions were characterized as ellipsoidal particles and were found to contain 62 circular DNA segments, totaling around 240 kb, with a GC content similar to other ichnoviruses.
  • * Genetic analysis revealed multiple gene families in DfIV, some unique to this virus, with notable similarities to another ichnovirus and certain segments indicating integration motifs from lepidopteran hosts, alongside differential gene expression during the wasps' developmental stages
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Background: Automatic diagnosis of depression based on speech can complement mental health treatment methods in the future. Previous studies have reported that acoustic properties can be used to identify depression. However, few studies have attempted a large-scale differential diagnosis of patients with depressive disorders using acoustic characteristics of non-English speakers.

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Here we report a case of successful heart transplantation (HT) in a patient with high risk on HT due to her complex congenital heart disease and its consequent complications; physiologic single lung and severe pulmonary arterial hypertension. HT was successfully performed in our patient using meticulous perioperative management techniques, such as control of collateral vessels, appropriate donor selection, pulmonary vasodilator therapy, post-transplant extracorporeal membranous oxygenation support, and atrial septostomy for right ventricular unloading.

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  • * The researchers discovered that all isolates carried certain genes, with only three showing the presence of an emetic toxin gene, suggesting some level of toxicity.
  • * The findings highlight the risk of foodborne infections, as moderate biofilm-forming strains showed resistance to antibiotics and could carry virulent traits.
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Purpose: To investigate the effects of deep learning-based imaging reconstruction (DLR) on the image quality of MRI of rectal cancer after chemoradiotherapy (CRT), and its accuracy in diagnosing pathological complete responses (pCR).

Methods: We included 39 patients (men: women, 21:18; mean age ± standard deviation, 59.1 ± 9.

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A formal screening of self-complementary adeno-associated virus (scAAV) vector serotypes in canine joint tissues has not been performed to date. Selecting appropriate serotypes is crucial for successful treatment due to their varying levels of tissue tropism. The objective of this study is to identify the most optimal scAAV vector serotype that maximizes transduction efficiencies in canine cell monolayer cultures (chondrocytes, synoviocytes, and mesenchymal stem cells) and tissue explant cultures (cartilage and synovium).

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