Factors distinguishing leukemoid reaction from hematological malignancy in children.

Background: Information on the etiology and prognosis for leukemoid reaction (LR) in children is still limited and little is known about the factors that distinguish LR from hematological malignancy (HM).

Methods: This was a single-center, case-control study. Pediatric patients (<18 years) with a white blood cell (WBC) count of 50,000/μL or more were included in the study.

Solvent-Driven Na Storage in SnS Anodes: Atomistic Simulation-Guided Strategies for Reversible Reactions, Solid Electrolyte Interphase, and Morphological Transformation.

Crystalline SnS accommodates Na ions through intercalation-conversion-alloying (ICA) reactions, exhibiting a natural potential for high energy storage, while its layered structure facilitates rapid charging. However, these intrinsic advantages are not fully realized in practical battery applications. Herein, utilizing an innovative integration of machine-learning-based thermodynamics, artificial-neural-network-assisted molecular dynamics, and density functional theory, specific solvents are demonstrated to effectively tailor the reaction pathways.

Near-Normalized Maxillomandibular Relationship and Upper Airway in Infants with Robin Sequence Treated with Stanford Orthodontic Airway Plate: Computed Tomography Study.

Objective: To assess craniofacial and upper airway growth in infants with Robin sequence (RS) during the 1 year of life when their severe upper airway obstruction was treated non-surgically with the Stanford orthodontic airway plate treatment program (SOAP).

Design: Retrospective longitudinal cohort study comparing SOAP-treated infants with RS (treatment group) with age-matched healthy controls (HC) using computed tomography (CT).

Setting: Single tertiary referral hospital.

Global Impact of Aging on the Hemodynamic Response Function in the Gray Matter of Human Cerebral Cortex.

In functional magnetic resonance imaging, the hemodynamic response function (HRF) is a stereotypical response to local changes in cerebral hemodynamics and oxygen metabolism due to briefly (< 4 s) evoked neural activity. Accordingly, the HRF is often used as an impulse response with the assumption of linearity in data analysis. In cognitive aging studies, it has been very common to interpret differences in brain activation as age-related changes in neural activity.

Semantic segmentation models with frozen weights for railway track detection.

In recent years, the application of pretrained models in specialized domains has become increasingly important. Traditionally, adapting these models involved fine-tuning their parameters and structures through retraining. However, these fine-tuning methods can be inefficient, particularly when addressing data from specific domains or when modifications are needed in the lower layers of large-scale pretrained models.

Genomic characterization and histologic analysis of uterine leiomyosarcoma arising from leiomyoma with bizarre nuclei.

Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with a benign clinical course. In contrast, leiomyosarcoma (LMS) is a high-grade, malignant neoplasm characterized by high recurrence rates and poor survival. While LM-BN and LMS show distinct morphologies, they share similar immunoprofiles and molecular alterations, with both considered 'genomically unstable'.

High-throughput microfluidic spheroid technology for early detection of colistin-induced nephrotoxicity with gradient-based analysis.

Colistin is essential for treating multidrug-resistant Gram-negative bacterial infections but has significant nephrotoxic side effects. Traditional approaches for studying colistin's nephrotoxicity are challenged by the rapid metabolism of its prodrug, colistin methanesulfonate and the difficulty of obtaining adequate plasma from critically ill patients. To address these challenges, we developed the Spheroid Nephrotoxicity Assessing Platform (SNAP), a microfluidic device that efficiently detects colistin-induced toxicity in renal proximal tubular epithelial cell (RPTEC) spheroids within 48 hours using just 200 μL of patient plasma.

Systemic Effects of Molar and Incisor Biting on Walking Direction With and Without Visual Feedback.

Gait stability and walking direction control are conventionally attributed to coordination among somatosensory, visual, and vestibular systems. Recent evidence of functional interdependence between masticatory and neuromuscular systems indicates that the stomatognathic system is neurologically integrated with various body systems relevant to movement planning and execution. This study investigated the effects of unilateral molar biting and incisor biting on walking with and without visual feedback.

Implementation of maternal death audits and changes in maternal health care in Cambodia, 2010-2017.

Objective: Cambodia is one of seven countries globally that met Millennium Development Goal 5A: reduction of maternal deaths by at least 75% between 1990 and 2015. The maternal death audit (MDA) was instituted in 2004 to support the improvement of maternal care. We evaluated progress in MDA implementation and maternal health services in Cambodia between 2010 and 2017.

Transradial-based thoracic branch endograft repair for thoracic aortic aneurysms experience at a suburban community hospital.

We present two cases where a transradial-based approach was used to implant thoracic branch aortic endografts to repair aortic aneurysms totally percutaneously. Both procedures were performed electively at a 330-bed suburban community hospital. No complications were associated with either procedure with both patients only requiring overnight observation and being discharged home the next day.

Gut-microbiota-based ensemble model predicts prognosis of pediatric inflammatory bowel disease.

Developing microbiome-based markers for pediatric inflammatory bowel disease (PIBD) is challenging. Here, we evaluated the diagnostic and prognostic potential of the gut microbiome in PIBD through a case-control study and cross-cohort analyses. In a Korean PIBD cohort (24 patients with PIBD, 43 controls), we observed that microbial diversity and composition shifted in patients with active PIBD versus controls and recovered at remission.

Identification of macrophages as an immune suppressor in hepatocellular carcinoma using single-cell and bulk transcriptomics.

Introduction: Macrophages and T cells play crucial roles in liver physiology, but their functional diversity in hepatocellular carcinoma (HCC) remains largely unknown.

Methods: Two bulk RNA-sequencing (RNA-seq) cohorts for HCC were analyzed using gene co-expression network analysis. Key gene modules and networks were mapped to single-cell RNA-sequencing (scRNA-seq) data of HCC.

A comparison of the physiochemical features of three tertiary hybrid pigs with and without spent coffee ground supplementation.

The objective of this experiment was to evaluate the physiochemical characteristics of three tertiary hybrids (crossbreeds) of pigs, with and without coffee supplementation. A total of fifty pigs of different mixed breeds Landrace × Yorkshire × Duroc (LYD), Yorkshire × Berkshire (YB), and Yorkshire × Woori (YW); 113.45 kg ± 3.

Response to environmental enrichment of weanling pigs on growth, behaviour and welfare after weaning.

The experiment was carried out to examine the growth, behaviour, and welfare response of weaning pigs to environmental enrichment from d 1 to d 28 after weaning. A total of 240 weaning pigs with average initial body weight (BW) 6.56 ± 0.

Conception rate according to the size and location of corpus luteum and coexistent follicle before embryo transfer in Hanwoo.

The size and location of the corpus luteum and the presence of coexistent follicles are crucial factors in synchronizing recipients and determining the suitability for embryo transfer. However, there has been a recent decline in conception rates after embryo transfer, which is attributed to environmental pollution, uterine inflammation, ovarian cysts, and other factors. Therefore, we conducted experiments to establish a novel criterion for successful embryo transfer assessment.

Effects of Italian ryegrass with multi-enzymes supplementation on growth performance, gut microbial, and manure odor emission in finisher pig.

This study investigated the effects of addition of Italian ryegrass with multi-enzyme on growth performance, fecal odor, and microbiome. The experiment had a two-factor factorial design, using three levels of Italian ryegrass (0%, 2.5%, and 5%) and two levels of multi-enzymes (no enzyme and commercially recommended level) to formulate experimental diets.

Long noncoding RNA network for lncRNA-mRNA interactions throughout swine estrous cycle reveals developmental and hormonal regulations in reproductive tissues.

The mechanism of estrous cycles of pigs should be explored because their reproductive traits are useful for manipulating productivity and solving problems such as infertility. These estrous cycles should be elucidated to understand the complex interactions between various reproductive tissues (including the ovary, oviduct, and endometrium) and the complex range of hormone secretions during estrous cycles. Long non-coding RNAs (lncRNAs) regulate target genes at transcriptional, post-transcriptional, and post-translational regulation levels in various species.

Taste-related and volatile organic compounds of fresh and frozen-thawed chicken breast meat.

The effect of frozen storage (-18°C for 2 months) and thawing (4°C for 16 h) on the taste-related compounds and volatile organic compounds (VOCs) in chicken breast meat was studied. After freeze-thawing, inosine monophosphate levels in chicken meat decreased and inosine levels increased. Free amino acid content increased significantly, regardless of bitter, sweet, or umami amino acids.

Characteristics of bovine muscle satellite cell from different breeds for efficient production of cultured meat.

The purpose of this study was comparing performances of three breeds of donor satellite cells for cultured meat and selecting the optimal donor and providing insight into the selection of donors for cultured meat production. Cattle muscle satellite cells were isolated from the muscle tissue of Hanwoo, Holstein, and Jeju black cattle, and then sorted by fluorescence activated cell sorting (FACS). Regarding proliferation of satellite cells, all three breeds showed similar trends.

Complete genome sequence of sp. SCR221107, encoding biosynthesis of vitamin B isolated from the rumen fluid of Holstein dairy cows.

sp. SCR221107 was isolated from the rumen fluid of healthy male Holstein dairy cows from a research farm at Suncheon, Jeollanam-do, Korea. sp.

Nutritional value of common carbohydrate sources used in pet foods.

Diet digestibility can vary based on factors such as the type of ingredients, processing techniques, formulation, fiber content, and nutrient interactions. Unlike proteins and fats, there is no specific carbohydrate requirement, which typically constitutes 30%-60% of commercial dried dog foods. Because of the significant proportion of carbohydrates in dog food, this study aimed to evaluate the differences in nutrient digestibility among barley, brown rice, corn, mung bean, and rice, which are common carbohydrate sources in commercial dog foods.

Evaluation of the nutrient digestibility at each age in dogs diet by and methods.

The objective of this study was to evaluate predictions of digestibility at each age (puppy, adult, and senior) in dogs of dry matter (DM), organic matter (OM), crude protein (CP), gross energy (GE), crude fiber (CF), and ether extract (EE) using dog diets. First, to determine the digestibility of dog diets using pepsin and pancreatin incubations, conduct the method. Later, 18 mixed-sex beagles were used in this experiment to compare digestibility.

Transcription factors and hormone receptors: Sex‑specific targets for cancer therapy (Review).

Despite advancements in diagnostic and therapeutic technologies, cancer continues to pose a challenge to disease-free longevity in humans. Numerous factors contribute to the onset and progression of cancer, among which sex differences, as an intrinsic biological condition, warrant further attention. The present review summarizes the roles of hormone receptors estrogen receptor α (ERα), estrogen receptor β (ERβ) and androgen receptor (AR) in seven types of cancer: Breast, prostate, ovarian, lung, gastric, colon and liver cancer.

Defining Echocardiographic Degrees of Right Heart Size and Function in Pulmonary Vascular Disease from the PVDOMICS Study.

Background: Defining qualitative grades of echocardiographic metrics of right heart chamber size and function is critical for screening, clinical assessment, and measurement of therapeutic response in individuals with pulmonary vascular disease (PVD). In a population enriched for PVD, we sought to establish qualitative grades and prognostic value of right heart chamber size and function.

Methods: We investigated 1053 study participants in the Redefining Pulmonary Hypertension through PVD Phenomics program (PVDOMICS) to determine clinical and echocardiographic differences associated with increasing pulmonary vascular resistance (PVR) severity.