The relationship between clinical prognostic factors, microvascular density, and tumor-infiltrating lymphocytes with CD47 and SIRPα expression in diffuse large B cell lymphomas.

CD47 interacts with signal regulatory protein alpha (SIRPα) on macrophages to deliver an anti-phagocytic signal, enabling tumor cells to evade immune destruction. This study explores the relationship between CD47 and SIRPα expression and key clinical prognostic factors, microvascular density (MVD), and tumor-infiltrating lymphocytes (TIL) in Diffuse Large B Cell Lymphoma (DLBCL) cases. We analyzed tissue samples from 122 DLBCL cases using tissue microarray (TMA) blocks and immunohistochemical staining for CD47, SIRPα, CD31, and CD3.

A rare diagnosis of primary fibrosarcoma of the thyroid - Case report and mini-review.

Malignant mesenchymal thyroid tumors are one of the rarest types of thyroid cancer. Clinically, these tumors present as a rapidly growing thyroid mass. Due to their rarity and nonspecific findings, they are not the first conditions that come to mind during differential diagnosis.

Timing of the repeat thyroid fine-needle aspiration biopsy: does early repeat biopsy change the rate of nondiagnostic or atypia of undetermined significance cytology result?

Purpose: To determine whether early repeat fine needle aspiration biopsy (FNA) has an effect on adequate or atypia of undetermined significance (AUS) cytology rates in thyroid nodules with inadequate or AUS result in the first FNA.

Methods: Nodules of patients who underwent repeat biopsy due to insufficient or AUS cytology between 2019-2022 were included. Data of the patients and ultrasonographic, cytological and histopathological results of the nodules were recorded.

Evaluation of erector spinae plane block in cardiac surgery patients in terms of acute and chronic pain scores.

Objective: Pain after cardiac surgery is a frequently encountered morbidity associated with poor quality of life and postoperative recovery. There have been several regional anesthesia modalities for this purpose. We aimed to investigate acute and chronic postoperative analgesic effects of erector spinae plane block (ESPB) after cardiac surgery.

Should Special Staining (AB/PAS) be Routinely Performed in Gastric Biopsies for the Detection of Intestinal Metaplasia?

Gastric intestinal metaplasia increases the risk of gastric cancer by nine times. Although attempts are made to diagnose it using endoscopic methods, the final diagnosis is established by examining and reporting biopsy samples. Although there are studies in the literature that do not recommend routine special staining, many laboratories routinely perform alcian blue/periodic acid Schiffs (AB/PAS) staining, in addition to hematoxylin and eosin (H&E) staining.

"We the BE": An educational mobile health application for children and families affected by bladder exstrophy-epispadias-cloacal exstrophy complex.

Goals: Despite the proliferation of over 45 000 smartphone mobile health applications (MHAs), as far as we know, there is no MHA for those living with rare diseases such as Bladder Exstrophy-Epispadias-Cloacal Exstrophy complex (BEEC). We hypothesized that an MHA could provide similar "on-demand" information and connectivity within health communities for patients with BEEC as they do for more common diseases. Thus, our primary goal was to create an MHA for patients and families affected by BEEC to provide them with important information about the condition and a format for them to connect with other affected patients and families.

How Can We Diagnose Ocular Surface Squamous Neoplasia With Optical Coherence Tomography?

Aim: We aimed to evaluate the effectiveness of optical coherence tomography (OCT) in the differential diagnosis of anterior segment diseases such as ocular surface squamous neoplasia (OSSN) and pterygium.

Methods: Patients who were pre-diagnosed with either OSSN (21) or pterygium (19) between January 2020 and November 2022 were included in this retrospective study. Anterior segment photographs and anterior segment optical coherence tomography (AS-OCT) measurements were obtained from each patient.

Application of different methods used to measure the apparent diffusion coefficient of renal cell carcinoma on the same lesion and its correlation with ISUP nuclear grading.

Purpose: To determine the most frequently used different apparent diffusion coefficient (ADC) measurement methods in renal cell carcinoma (RCC), and their correlation with the International Society of Urological Pathology (ISUP) histologic grading system.

Methods: A total of 99 patients who underwent diffusion-weighted imaging and whose pathologic diagnosis of RCC was confirmed were included in the study. As a result of a literature review, region of interest (ROI) selection and measurement methods were determined in five ways.

A larval granuloma in the lung: An extremely rare phenomenon.

The formation of pulmonary nodules is associated with benign or malignant pathologies. Based on the sizes, growth rates, and morphological features of nodules, surgical treatment or follow-up can be performed. Pulmonary nodules are frequently encountered in the practice of thoracic surgery.

Ultrasonographical, clinical and histopathological features of 1264 nodules with papillary thyroid carcinoma and microcarcinoma based on tumor size.

Objective: We aimed to evaluate the patients diagnosed with papillary thyroid carcinoma (PTC) and papillary thyroid microcarcinoma (PTMC) in terms of clinical, ultrasonographical (US) and histopathological features and their relationships with tumor size.

Methods: We retrospectively evaluated 881 patients who underwent thyroid surgery in our clinic and diagnosed with PTC histopathologically were enrolled the study. Demographic characteristics, US findings and histopathological features were evaluated.

HADS-depression score is a mediator for illness perception and daily life impairment in Takayasu's arteritis.

Introduction/objectives: The aim of this study was to evaluate the relationships among the disease activity, illness perception, daily life performance, anxiety and depression status as potential mediators in Takayasu's arteritis (TAK) patients.

Method: In this cross-sectional study, 77 TAK patients were included. Data were collected by a clinical examination and a structured questionnaire regarding patient reported outcome measures (PROMs).

Evaluation of corneal topography, tear film function and conjunctival impression cytology after long-term scleral contact lens wear in keratoconus patients.

: To investigate the impact of long-term scleral contact lens (ScCL) wear on corneal curvature, corneal thickness, tear film function, and ocular surface in patients with keratoconus.: Sixteen keratoconus patients wearing ScCLs for 6 months were enrolled in the study. Corneal topography, tear osmolarity test, Schirmer 1 test, tear film break-up time (TBUT) test, and impression cytology analysis were assessed at baseline and follow-up examinations.

Towards a Portable Magnetoencephalography Based Brain Computer Interface with Optically-Pumped Magnetometers.

Brain Computer Interfaces (BCIs) allow individuals to control devices, machines and prostheses with their thoughts. Most feasibility studies with BCIs have utilized scalp electroencephalography (EEG), due to it being accessible, noninvasive, and portable. While BCIs have been studied with magnetoencephalography (MEG), the modality has limited applications due to the large immobile hardware.

The Triple Positivity for EBV, PD-1, and PD-L1 Identifies a Very High Risk Classical Hodgkin Lymphoma.

Background: The programmed death receptor (PD-1) and ligand (PD-L1) pathway act by suppressing the antitumor response in chronic Hodgkin lymphoma (cHL). In this study, we aimed to investigate the effect of PD-1, PD-L1, and Epstein-Barr virus (EBV) positivity on prognosis at the initial diagnosis of cHL.

Material And Methods: Thirty-six patients with cHL were retrospectively analyzed.

Classification and Transfer Learning of EEG during a Kinesthetic Motor Imagery Task using Deep Convolutional Neural Networks.

The reliable classification of Electroencephalography (EEG) signals is a crucial step towards making EEG-controlled non-invasive neuro-exoskeleton rehabilitation a practical reality. EEG signals collected during motor imagery tasks have been proposed to act as a control signal for exoskeleton applications. Here, a Deep Convolutional Neural Network (DCNN) was optimized to classify a two-class kinesthetic motor imagery EEG dataset, leading to an optimized architecture consisting of four convolutional layers and three fully connected layers.

Towards a Unified Framework for De-noising Neural Signals.

Neural signals provide key information for decision-making processes in multiple disciplines including medicine, engineering, and neuroscience. The correct interpretation of these signals, however, requires substantial processing, especially when the signals exhibit low Signal to Noise Ratio (SNR). Electroencephalographic (EEG) signals are considered among this group and require effective handling of multiple types of artifactual components.

Tear function and ocular surface changes following corneal collagen cross-linking treatment in keratoconus patients: 18-month results.

Purpose: To investigate the long-term effects that CXL has on the tear function and ocular surface in keratoconus.

Methods: Twenty-one consecutive patients (24 eyes) with progressive keratoconus scheduled for CXL were included. All patients underwent the following procedures: conjunctival impression cytology analysis, ocular surface disease index (OSDI) score, tear osmolarity test, Schirmer test, tear film breakup time (TBUT), ophthalmic surface fluorescein (Fl) staining, and topographical corneal evaluation before as well as 3 and 18 months after accelerated CXL.

Characterization and real-time removal of motion artifacts from EEG signals.

Objective: Accurate implementation of real-time non-invasive brain-machine/computer interfaces (BMI/BCI) requires handling physiological and nonphysiological artifacts associated with the measurement modalities. For example, scalp electroencephalographic (EEG) measurements are often considered prone to excessive motion artifacts and other types of artifacts that contaminate the EEG recordings. Although the magnitude of such artifacts heavily depends on the task and the setup, complete minimization or isolation of such artifacts is generally not possible.