Overthinking over Screens: Girls Ruminate More After Negative Social Media Interactions with Peers Compared to In-Person Interactions.

With the rise and ubiquity of social media (SM), the context for peer interactions has changed drastically for adolescents, yet, little is known about how digital peer interactions compare to in-person interactions in their impact on adolescents' emotional experiences. Adolescents employ various emotion regulation (ER) strategies to navigate the complexities of peer interactions, with varying strategy adaptiveness and efficacy. This study delves into the prevalence of ER strategies following daily negative peer interactions on SM, exploring to what extent context (SM or in-person) influences the selection of ER strategies.

The Role of Neural Sensitivity to Social Evaluation in Understanding "for Whom" Social Media Use May Impact Emotional Health During Adolescence.

There is much interest in the role of social media (SM) in the current mental health crisis among teens. In this review, we focus on the question of "for whom" SM experiences have the strongest impact on emotional health, considering neural sensitivity to social evaluation as a potential vulnerability factor that makes youth more susceptible to the effects of SM. We first present behavioral evidence showing that sensitivity to social evaluation moderates the link between SM use and emotional health in youth.

Phosphorus-Nitrogen Compounds: Part 76. Design and Syntheses of Dispiro- and Trispiro(N/N)cyclotriphosphazenes: Conformational and Structural Analyses, Chirality, Electrochemical, Dye-Sensitized Solar Cells, and Bioactivity Studies.

The reactions of monospirocyclotriphosphazenes ( and ) with -methyl-1,3-diaminopropane gave unsymmetrical -( and ) and -( and ) dispirocyclotriphosphazenes. Trans-cis-trans () ( and ), cis-cis-cis () ( and ), trans-trans-cis () ( and ), and cis-trans-trans () () trispirocyclotriphosphazenes were obtained from the reactions of and and and with -methyl-1,3-diaminopropane. -Dispirocyclotriphosphazenes ( and ) exist as "pseudomesoracemates", while -dispirocyclotriphosphazenes ( and ) are in "racemates".

BNP-Track: a framework for superresolved tracking.

Superresolution tools, such as PALM and STORM, provide nanoscale localization accuracy by relying on rare photophysical events, limiting these methods to static samples. By contrast, here, we extend superresolution to dynamics without relying on photodynamics by simultaneously determining emitter numbers and their tracks (localization and linking) with the same localization accuracy per frame as widefield superresolution on immobilized emitters under similar imaging conditions (≈50 nm). We demonstrate our Bayesian nonparametric track (BNP-Track) framework on both in cellulo and synthetic data.

Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function.

Integral membrane proteins (IMPs) play central roles in cellular physiology and represent the majority of known drug targets. Single-molecule fluorescence and fluorescence resonance energy transfer (FRET) methods have recently emerged as valuable tools for investigating structure-function relationships in IMPs. This review focuses on the practical foundations required for examining polytopic IMP function using single-molecule FRET (smFRET) and provides an overview of the technical and conceptual frameworks emerging from this area of investigation.

Recovering true FRET efficiencies from smFRET investigations requires triplet state mitigation.

Single-molecule fluorescence resonance energy transfer (smFRET) methods employed to quantify time-dependent compositional and conformational changes within biomolecules require elevated illumination intensities to recover robust photon emission streams from individual fluorophores. Here we show that outside the weak-excitation limit, and in regimes where fluorophores must undergo many rapid cycles of excitation and relaxation, non-fluorescing, excitation-induced triplet states with lifetimes orders of magnitude longer lived than photon-emitting singlet states degrade photon emission streams from both donor and acceptor fluorophores resulting in illumination-intensity-dependent changes in FRET efficiency. These changes are not commonly taken into consideration; therefore, robust strategies to suppress excited state accumulations are required to recover accurate and precise FRET efficiency, and thus distance, estimates.

Radiation-induced lumbosacral plexopathy and pelvic insufficiency fracture: A case report of unique coexistence of complications after radiotherapy for prostate cancer.

Case reports of plexopathy after prostate cancer are usually neoplastic. Radiation-induced lumbosacral plexopathy and insufficiency fractures have clinical significance due to the need to differentiate them from tumoral invasions, metastases, and spinal pathologies. Certain nuances, including clinical presentation and screening methods, help distinguish radiation-induced plexopathy from tumoral plexopathy.

Gene expression model inference from snapshot RNA data using Bayesian non-parametrics.

Gene expression models, which are key towards understanding cellular regulatory response, underlie observations of single-cell transcriptional dynamics. Although RNA expression data encode information on gene expression models, existing computational frameworks do not perform simultaneous Bayesian inference of gene expression models and parameters from such data. Rather, gene expression models-composed of gene states, their connectivities and associated parameters-are currently deduced by pre-specifying gene state numbers and connectivity before learning associated rate parameters.

The relationship between perception of COVID-19, fear of COVID-19 and self-care management in individuals with chronic diseases during the pandemic process in Turkey.

Aims: To determine the relationship between perception of COVID-19, fear of COVID-19 and self-care management in individuals with chronic diseases during the pandemic process.

Background: Individuals with chronic diseases are a sensitive group during the COVID-19 pandemic process; it is thought that self-care management may be adversely affected as a result of their more intense exposure to the psychological, physiological and economic effects of the pandemic. In the literature, there is no study examining the effect of perception of COVID-19 and fear of COVID-19 on self-care management in individuals with chronic diseases.

Single-Molecule Reaction-Diffusion.

We propose to capture reaction-diffusion on a molecule-by-molecule basis from the fastest acquirable timescale, namely individual photon arrivals. We illustrate our method on intrinsically disordered human proteins, the linker histone H1.0 as well as its chaperone prothymosin , as these diffuse through an illuminated confocal spot and interact forming larger ternary complexes on millisecond timescales.

The effect of cognitive flexibility in nurses on attitudes to professional autonomy.

Background: Professional autonomy, which directly affects the quality of professional nursing in patient care, and cognitive flexibility, which is an important factor for adaptation to change and developing nursing roles, are important concepts for nursing.

Research Objectives: This research was carried out to determine the effect of cognitive flexibility on attitudes towards professional autonomy in nurses.

Research Design: This was a descriptive study.

Monte Carlo samplers for efficient network inference.

Accessing information on an underlying network driving a biological process often involves interrupting the process and collecting snapshot data. When snapshot data are stochastic, the data's structure necessitates a probabilistic description to infer underlying reaction networks. As an example, we may imagine wanting to learn gene state networks from the type of data collected in single molecule RNA fluorescence in situ hybridization (RNA-FISH).

Abuse and addiction in gabapentinoid drug users for neuropathic pain.

Objective: Gabapentinoids are gamma-aminobutyric acid analogue agents used in the treatment of neuropathic pain. They are increasingly being abused to achieve euphoric and dissociative effects. This study aimed to determine drug misuse/abuse and related factors in patients who used gabapentinoids for neuropathic pain.

Two-state swimming: Strategy and survival of a model bacterial predator in response to environmental cues.

Bdellovibrio bacteriovorus is a predatory bacterium preying upon Gram-negative bacteria. As such, B. bacteriovorus has the potential to control antibiotic-resistant pathogens and biofilm populations.

Cascading bidirectional influences of digital media use and mental health in adolescence.

A substantial portion of critical adolescent development is occurring within digital environments. However, certain individual differences may lead adolescents to use digital media in diverse ways. In this chapter we suggest that the way teens use digital media influences how digital media affects their mental health.

BNP-Track: A framework for multi-particle superresolved tracking.

When tracking fluorescently labeled molecules (termed "emitters") under widefield microscopes, point spread function overlap of neighboring molecules is inevitable in both dilute and especially crowded environments. In such cases, superresolution methods leveraging rare photophysical events to distinguish static targets nearby in space introduce temporal delays that compromise tracking. As we have shown in a companion manuscript, for dynamic targets, information on neighboring fluorescent molecules is encoded as spatial intensity correlations across pixels and temporal correlations in intensity patterns across time frames.

CFTR function, pathology and pharmacology at single-molecule resolution.

The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that regulates salt and fluid homeostasis across epithelial membranes. Alterations in CFTR cause cystic fibrosis, a fatal disease without a cure. Electrophysiological properties of CFTR have been analysed for decades.

Pneumatic Dilation in Geriatric Achalasia Patients.

Background: The aim of the study was to share the effectiveness of pneumatic dilation in geriatric achalasia patients.

Methods: Achalasia patients over the age of 65 and those under the age of 65 as the control group who received pneumatic dilation as the first-line treatment were evaluated in the study.

Results: The average age of geriatric patients was 72.

Leveraging Baird aromaticity for advancement of bioimaging applications.

In this perspective, we highlight the recent progress in utilizing Baird aromatic species to improve fluorophore performance in microscopy and imaging applications. We specifically focus on the origins of the use of Baird aromaticity in fluorescence applications, the development of “self‐healing” fluorophores leveraging cyclooctatetraene’ Baird aromaticity, and where developments need to occur to optimize this technology.

The Effect of Progressive Relaxation Exercises on Dyspnea and Anxiety Levels in Individuals With COPD: A Randomized Controlled Trial.

Dyspnea is a common symptom and anxiety is a common comorbidity of chronic obstructive pulmonary disease (COPD). They affect individuals with COPD in a multifaceted way, causing many disabilities. Progressive relaxation exercises (PREs) are an important intervention in reducing symptoms and comorbidity.

Relationship Among , Lower Esophagus Sphincter Pressure, and Gastroesophageal Reflux: A Single-Center Experience.

Objectives: The aim of the study was to evaluate the relationship among lower esophageal sphincter pressure (LESP), (Hp), and gastroesophageal reflux (GER).

Methods: The retrospective study included patients with isolated hypertensive or hypotensive lower esophageal sphincter (LES) who underwent esophageal manometry in our gastroenterology motility laboratory and had normal manometry results. Demographic characteristics, complaints on admission, upper endoscopy findings, 24-h esophageal pH monitoring results, and presence of Hp in gastric biopsy were evaluated.

Vascularized Bone Grafting in the Treatment of Scaphoid Nonunion: A Clinical and Functional Outcome Study.

 A malreduction or missed scaphoid fracture may lead to nonunion or avascular necrosis (AVN). The aim of this study was to analyze the radiological and clinical outcome of patients with scaphoid nonunion (SN), who were treated with 1,2-intercompartmental supraretinacular artery pedicled vascularized bone graft (1,2-ICSRA-VBG) fixed with K-wires or screws between 2014 and 2018.  Radiological assessment included posteroanterior, lateral, oblique, and angled posteroanterior projection.

The COVID-19 pandemic and problematic usage of the internet: Findings from a diverse adult sample in South Africa.

Background: The coronavirus disease 19 (COVID-19) has led to increased reliance on the internet. How problematic usage of the internet (PUI) and COVID-19 related stress and other clinical variables relate, is unknown. We hypothesised that higher PUI level would be significantly associated with higher levels of: (i) pandemic-related stress; and (ii) impulsive and compulsive symptoms and traits.