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Despite readily available alternative technologies, many antibodies in research and diagnostics are still generated and produced with the use of laboratory animals. Here, we portrait the concept of animal-free recombinant antibodies and the generation of such an antibody against the spike-protein of SARS-Cov-2. The scientific community needs to raise awareness for more sustainable animal-free alternatives, especially as they offer a path to more reliable and reproducible data.

Epitope Mapping via Phage Display from Single-Gene Libraries.

Antibodies are widely used in a large variety of research applications, for diagnostics and therapy of numerous diseases, primarily cancer and autoimmune diseases. Antibodies are binding specifically to target structures (antigens). The antigen-binding properties are not only dependent on the antibody sequence, but also on the discrete antigen region recognized by the antibody (epitope).